人脑GABA测量在临床3 T磁共振成像系统上的实现

摘要

GABA (γ-aminobutyric acid) is a major inhibitory neurotransmitter in the central nervous system of human brain,and plays a predominant role in the regulation of neuronal activity.Detection of GABA by in vivo magnetic resonance spectroscopy is hindered by its inherent low concentration and overlapping with resonances from other metabolites.GABA cannot be directly detected with the PRESS (point resolved echo spectroscopy) or STEAM (stimulated echo acquisition mode) pulse sequences on the clinical MRI scanners.This paper reported the implementation of a single-voxel spectroscopy J-difference editing sequence (MEGA-PRESS) for detection of GABA.The results from phantom studies and human brain indicated that it is feasible to use MEGAPRESS for detection of GABA on 3 T clinical MRI scanners.%γ-氨基丁酸(γ-Aminobutyric Acid,GABA)是人脑中枢神经系统中一种重要的抑制性神经递质,对神经活动的调节起着主导作用.由于人脑GABA固有含量低以及与其他代谢物谱峰的重叠,在临床用磁共振成像系统中使用点分辨波谱(PRESS)序列或受激回波采集模式(STEAM)序列难以直接检测到GABAδ3.01信号.该文报道了MEGA-PRESS脉冲序列在临床用3T磁共振成像系统上的实现,采用J差分谱编辑技术实现了对GABA的检测.水模实验和人脑在体实验显示,MEGA-PRESS序列对GABAδ3.01信号具有较好的检测效果.