手性硫脲在DMAP条件下对布洛芬类药物的NMR手性识别

摘要

The chiral recognition of racemic ibuprofen by thiourea was studied using 1H NMR spectroscopy. It was found that, with the participation of DMAP, excellent recognition of the enantiomers of ibuprofen by thiourea could be achieved, and the process was not affected by the chiral bisthiourea and DMAP. To evaluate the ability of the chiral bisthiourea/DMAP for enantiomeric determination, several ee. values of ibuprofen samples were determined by 1H NMR, and the results coincided with the theoretical value.%通过1H NMR 研究了手性硫脲对布洛芬类药物的手性识别．在4-二甲氨基吡啶(DMAP)的参与下，硫脲对布洛芬类化合物显示出良好的识别效果，并且布洛芬对映异构体的a-H NMR信号与硫脲和DMAP无相互干扰．为了检测硫脲/DMAP对手性布洛芬对映体纯度的分析能力，测定了若干ee.（对换体过量百分数）值的布洛芬溶液，与理论值吻合．