慢性高原病患者脑灰质变化的VBM-MRI研究

摘要

目的：采用MRI基于体素的形态学测量(VBM-MRI)技术，分析慢性高原病(CMS)患者全脑灰质体积的变化。材料与方法对14例临床确诊的CMS患者和年龄、性别、受教育年限、海拔高度相匹配的11例正常志愿者行全脑扫描，获取3D-T1结构图像。利用VBM方法对CMS组和正常组的全脑灰质图像进行基于体素的统计学比较。结果与对照组相比，CMS患者右侧舌回、后扣带回、双侧海马旁回及左侧颞下回灰质体积增加；左侧前扣带回灰质体积减少。结论利用VBM方法对MR结构图像分析能够客观显示CMS患者特定脑区体积的变化，从影像学角度揭示高原缺氧对脑结构的影响。%Objective:The aim of the study was to investigate the gray matter (GM) volumes alterations in Chronic Mountain Sickness (CMS) patients by using voxel-based morphometry method (VBM) of magnetic resonance imaging (MRI). Materials and Methods:14 cases of patients with clinically diagnosed CMS and age, sex, years of education, altitude matched 11 cases of normal volunteers underwent whole brain scan, and 3D-T1 structural images were acquired. Then we used the VBM method compared the whole brain GM differences between CMS group and normal controls. Results:Compared with the control group, increased GM volumes was found in the right lingual gyrus, right posterior cingulate, bilateral parahippocampa gyrus, left ilferior temporal gyrus in CMS group and we also found reduced GM volumes in left anterior cingulated. Conclusions:Based on magnetic resonance structural images, the VBM method could objectively display the volume changes of speciifc brain areas in CMS patients and revealed the impact of altitude hypoxia on brain structure from the perspective of imaging.