体素内不一致运动成像序列在贲门癌中的初步应用

摘要

目的：分析贲门癌体素内不一致运动(introvoxel incoherent motion， IVIM) MR成像的特点及其与正常贲门间IVIM各参数的差异。材料与方法回顾性分析20例贲门癌患者与贲门正常患者MRI资料，所有患者均行MR常规扫描和双指数模型IVIM扫描，并测量两组患者的IVIM得到的标准ADC、D、D*和f值，进行两组独立样本t检验分析。结果贲门癌组标准ADC、D、D*和f分别为(1.18±0.35)×10-3 mm2/s、(0.63±0.67)×10-3 mm2/s、(21.29±18.83)×10-3 mm2/s、0.37±0.37，贲门正常患者标准ADC、D、D*和f值分别为(1.56±0.38)×10-3 mm2/s、(1.32±1.06)×10-3 mm2/s、(8.59±3.98)×10-3 mm2/s、0.70±0.22，贲门癌组标准ADC、D、f值均低于正常组，D*值高于正常组，差异有统计学意义(t值分别为2.920、2.473、2.325、2.923；P=0.006、0.027、0.019、0.006)。贲门癌组、正常组标准ADC与D值差异均无统计学意义(t值分别为3.073、0.868；P=0.543、0.326)。结论贲门癌组标准ADC和D值较低、D*较高，具有一定特征性，有助于贲门癌的诊断。%Objective:To analyze introvoxel incoherent motion (IVIM) MR sequence features and the difference between carcinoma of gastric cardia and normal cardia. Materials and Methods:MR imaging data of 20 patients with gastric cardia carcinoma and 20 patients of normal cardia were analyzed retrospectively. All patients underwent routine MR scan and biexponential model IVIM sequence. The IVIM parameters (Standard ADC, D, D* and f) of gastric cardia carcinoma and normal cardia were measured and analyzed by using t test. Results:The Standard ADC, D, D*and f of gastric cardia carcinoma group were (1.18±0.35)×10-3 mm2/s, (0.63±0.67)×10-3 mm2/s, (21.29±18.83)×10-3 mm2/s, 0.37±0.37, and those of normal cardia group were (1.56±0.38)×10-3 mm2/s, (1.32±1.06)×10-3 mm2/s, (8.59±3.98)×10-3 mm2/s, 0.70±0.22. The differences of these parameters between two groups were statistically signiifcant (t=2.920, 2.473, 2.325, 2.923, P=0.006, 0.027, 0.019, 0.006). No differences showed between standard ADC and D in both gastric cardia and normal groups (t=3.073, 0.868, P=0.543, 0.326). Conclusions:The Standard ADC and D of gastric cardia carcinoma group showed lower than normal cardia group, the D*appeared higher than normal group, which may play a complementary role in the diagnosis of gastric cardia carcinoma.