磁共振灌注加权成像在宫颈癌表现特点的研究

摘要

Objective: To explore the perfusion differences among cervical cancer, normal cervixand cervical intermural leiomyomas with magnetic resonance. Materials and Methods:We collected 32 cases of cervical cancer patients, 30 cases of normal cervix and 30 cases of patients with cervical intermural leiomyomas.Time signal-intensity curve (TIC), maximum enhancement (ME), steepest slope (SSmax), Time To Peak (TTP), were measured and analyzed on perfusion weighted imaging. Besides, the correlation between characteristics of perfusion and hemodynamic enhancement was calculated. Results:In the TIC type of cervical cancer group,"rapidly wash in followed by a plateau"had 25 cases,"rapidly wash in followed by a slowly wash out"had 7 cases;in the TIC type of normal cervix group,"slow wash in"had 22 cases,"rapidly wash in followed by a plateau"had 8 cases;in the TIC type of cervica intermural leiomyomas group,"rapidly wash infollowed by a plateau"had 24 cases,"slowly wash in " had 6 cases. there are great statistically signiifcant differences between ME, SSmax, TTP of the cervical cancer group and the normal cervix group (P<0.001);there are also great statistically signiifcant differences between cervical cancer group and cervical intermural leiomyomas group (P<0.001). Conclusions:PWI could relfect the hemodynamic characteristics of cervical cancer well,which could help with the differential diagnosis of cervical cancer,and provide the reference for the clinical evaluation.%目的：探讨宫颈癌与正常宫颈、宫颈肌壁间肌瘤之间磁共振灌注加权成像(PWI)参数的差异。材料与方法通过磁共振灌注加权成像，获得32例宫颈癌患者与30例正常宫颈、30例宫颈肌壁间肌瘤患者的时间-信号强度曲线(TIC)、最大增强(ME)、首过最大灌注斜率(SSmax)、达峰时间(TTP)的数据，并进行对比分析，研究其灌注特性与血流动力学特征的相关性。结果宫颈癌组TIC曲线“速升平台”型25例，“速升缓降”型7例；正常组TIC曲线“缓慢上升”型22例，“速升平台”型8例；宫颈肌瘤组TIC曲线“速升平台”型24例，“缓慢上升”型6例。宫颈癌组的ME、SSmax、TTP与正常对照组的参数存在显著性差异(P＜0.001)，宫颈癌组与宫颈肌壁间肌瘤对照组各参数间亦存在显著性差异(P＜0.001)。结论 PWI能很好地反映宫颈癌血流动力学特征，有助于宫颈癌的鉴别诊断和临床治疗评估提供参考。