首发抑郁症脑局部一致性静息态MRI对比研究

摘要

Objective:To explore the abnormal active area of brain function in patients with depression and the impact of depressive mood to the patient’s brain function using resting-state functional MRI(rfMRI) technology. Materials and Methods:30 patients with depression [live up to DSM-IV diagnostic criteria for depression, Hamilton Depression Scale (HAMD-17) score≥17 points] and 30 healthy volunteers were examed by rfMRI. The difference between depression and normal control group was analyzed using the method of regional homogeneity (ReHo). Results:ReHo was signiifcantly higher than the control group in the brain area of Bilateral part of the brain the amount of depression group, temporal, parietal, and bilateral putamen, right caudate nucleus, amygdala, cortex, cerebellar vermis, etc, while in the brain area of bilateral prefrontal cortex, precuneus, lingual gyrus and cerebellum, etc. reduced signiifcantly (P<0.001, K>10) on ReHo chart analysis of depression group and normal control group. Conclusions: ReHo method can detect synchronised changes of regional cerebral tissue BOLD signal caused by depressed mood, more objectively relfect the functional state of the whole brain, thereby contribute to basic and clinical research of patients with depression.%目的利用静息态功能磁共振成像(resting-state functional MRI，rfMRI)技术，探索抑郁症患者异常脑功能活动区域及抑郁心境对患者脑功能的影响。材料与方法对30例抑郁症患者[符合DSM-IV抑郁症的诊断标准，汉密尔顿抑郁量表(HAMD-17)评分≥17分]和30例健康志愿者行rfMRI扫描。使用局部一致性(regional homogeneity，ReHo)方法对比分析ReHo在抑郁症组与正常对照组之间的不同。结果抑郁症组与正常对照ReHo图组间分析：抑郁症组大脑的双侧部分额、颞、顶叶、双侧壳核、右侧尾状核、杏仁核、扣带回、小脑蚓部等脑区的ReHo显著高于正常对照组，而在双侧前额叶、楔前叶、舌回及小脑半球等脑区ReHo显著减低(P<0.001, K>10)。结论 ReHo方法可检出抑郁心境造成的局部脑组织BOLD信号同步性的改变，更客观地反映全脑的功能状态，有助于抑郁症的基础和临床研究。