肿瘤异常蛋白检测系统在早期妇科恶性肿瘤筛查中的应用价值

摘要

Objective To investigate the application value of tumor abnormal protein (TAP)detection system in the early stage of gynecological malignant tumor screening.Methods 126 cases patients of suspected early stage of gyneco-logical malignant tumor were selected,there were 56 cases of malignant tumors and 70 cases of non-malignant tumors by pathological examination after operation,and ultrasonic and TAP detection were performed before operation in all patients.50 cases of the normal female health examination people were selected as control at the same period,and the sensitivity,specificity,positive predictive value and negative predictive values,and Youden index were observed by the TAP detection and ultrasonic diagnosis of early stage gynecological malignant tumor.Results ①The positive rate of TAP detection in malignant tumor patients was 89.29% which was higher than the non malignant tumor patient’s 14.29% and normal population of 4%,the difference was statistically significant(P <0.05),The difference between pa-tients with non malignant tumor and normal population was statistically significant(P <0.05);②The sensitivity,speci-ficity,Jorden index,index,positive predictive value,and negative predictive value respectively were 89.29%,85.57%, 74.86%,83.33%,90.90%,there were higher than the ultrasonic diagnosis of 75%,67.86%,82.28% that the sensitiv-ity,youden index,negative predictive value,and the specificity was lower than ultrasonic diagnosis of 92.86%,so the difference was statistically significant(P <0.05).Conclusion The sensitivity will be higher than the ultrasonic exami-nation that TAP detection system in the early stage of gynecological malignant tumor screening and it will have a good reference value.%目的：探讨肿瘤异常蛋白（TAP）检测系统在早期妇科恶性肿瘤筛查中的应用价值。方法选择早期妇科恶性肿瘤疑似患者126例，经术后病理学检查包括恶性肿瘤56例，非恶性肿瘤70例，所有患者术前均行超声与 TAP检测；同期选择正常女性体检人群50例，作为对照，观察 TAP 检测与超声诊断早期妇科恶性肿瘤的灵敏度、特异度、阳性预测值、阴性预测值及约登指数。结果①恶性肿瘤患者 TA P 检测阳性率为89．29％，高于非恶性肿瘤患者与正常人群的14．29％、4％，比较差异有统计学意义（P ＜0．05），非恶性肿瘤患者与正常人群比较差异亦有统计学意义（P ＜0．05）；②TAP 筛查妇科早期恶性肿瘤灵敏度、特异度、约登指数、阳性预测值、阴性预测值分别为89．29％、85．57％、74．86％、83．33％、90．90％，灵敏度、约登指数、阴性预测值高于超声诊断的75％、67．86％、82．28％，特异度低于超声诊断的92．86％，比较差异均有统计学意义（P ＜0．05）。结论TAP 检测系统筛查早期妇科恶性肿瘤较超声检查灵敏度更高，具有良好的参考价值。