影像引导经皮冷冻消融术治疗肿瘤应用进展

摘要

Percutaneous imaging-guided cryoablation (PICA) is a recently developed technique,which applies extreme hypothermia to destroy tumors guided with CT,MRI or ultrasound images.Compared with other oncologic cryoablation therapies,PICA has some advantages,such as treating under local anesthesia,superior monitoring capability on multimodal imaging,less intraoperative and postoperative pain and preservation of tissue collagenous architecture.In recent years,PICA has been used in treatment of tumors in lung,liver,kidney,breast,prostate and so on.In this article,the principle of cryoablation and the application progresses of PICA in oncotherapy were reviewed.%影像引导经皮冷冻消融术(PICA)是在CT、MR以及超声引导下对肿瘤进行快速降温和复温,从而彻底破坏肿瘤组织的一种新兴的治疗技术.与其他消融技术相比,PICA具有独特优势,如局部麻醉下操作、可利用多模态影像介导、术中及术后疼痛症状轻微、对胶原组织损伤较小等.近年来,PICA已用于临床治疗肺、肝、肾、乳腺、前列腺等部位的肿瘤.本文主要对冷冻消融的原理及PICA在肿瘤治疗中的应用进展进行综述.