八味通络颗粒治疗舒张性心力衰竭30例临床观察

摘要

Objective To observe the effect of Bawei Tongluo granule on diastolic heart failure. Methods Sixty patients (pts) with diastolic heart failure were randomly divided into two groups:Control group(n= 30)treated with routine treatment,and freat ment group(n=30) treated with Bawei Tongluo granule and routine treatment for 8 weeks. The NYHA heart function and symptoms of traditional Chinese medicine(TCM) were studied before and after treatment. Early diastolic mitral flow peak velocity( E) , late diastolic peak flow velocity(A), E/A ratio,isovolumic relaxation time (IVRT), E peak acceleration time (ACTe) and deceleration time (DCTe) were compared by echocardiography. Results After treatment,the NYHA heart function was no significant difference(P＞0.05).TCM efficacy was significantly different between treatment group and control group there (P＞0.05). Early diastolic peak flow velocity(E), late diastolic peak flow velocity (A), E/A, IVRT and DCTe after treatment were imroved significantly(P＜0.05). The late diastolic peak flow velocity(A),DCTe in treatment group were lower(P＜0. 05) ,and E/A was increased significantly(P＜0.05) compared with control group. Conclusion Bawei Tongluo granule could improve left ventricular diastolic function.%目的 观察八味通络颗粒治疗舒张性心力衰竭的临床疗效.方法 将60例舒张性心力衰竭患者随机分为对照组和治疗组,每组30例,两组均给予常规西药治疗,治疗组加用八味通络颗粒,疗程8周.观察治疗后两组纽约心脏病学会(NYHA)心功能疗效、中医证候疗效,以及治疗前后超声心动图反映的左室舒张功能指标,包括二尖瓣舒张早期血流峰值速度(E)、舒张晚期血流峰值速度(A)、E/A比值、等容舒张时间(IVRT)、E峰加速时间(ACTe)和E峰减速时间(Dcte).结果 治疗后两组NYHA心功能疗效比较无统计学意义(P>0.05),中医证候疗效比较有统计学意义(P<0.05).超声心动图比较,治疗组治疗后E、A、E/A、IVRT及DCTe与治疗前比较有统计学意义(P<0.05);与对照组比较,治疗后治疗组A、DCTe明显降低(P<0.05),E/A明显增加(P<0.05).结论 八味通络颗粒能明显改善反映左室舒张功能的超声指标,可提高中医证候疗效.