丹参粉针剂对高血压患者凝血功能的影响

摘要

Objective To explore the effect of Salvia Miltiorrhiza on clotting function in the hypertensive patients. Methods One hundred and twenty hypertensive patients were enrolled and randomly divided into conventional anti - hypertension treatment group (n = 60), Salvia Miltiorrhiza group (n = 60), and 50 healthy subjects served as control group. Patients in Salvia Miltiorrhiza group were treated with Salvia Miltiorrhiza 400 mg qd on the basis of conventional anti - hypertension treatment for 2 weeks. Fibrinogen (Fg), platelet counts (PLT), thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), plasminogen activator inhibitor - 1 (PAI - 1), tissue plasminogen activator (t - PA) and D - dimmer (DD) were detected. Results Compared with control group, TT, PT and APTT decreased, Fg, PLT, PAI- 1 and DD increased, t-PA reduced in the hypertensive patients (all P< 0. 05). The TT, PT and APTT extended, Fg, PLT, PAI - 1 and DD decreased, t - PA increased in two groups after treatment, clotting function in Salvia Miltiorrhiza group were better than that in conventional group after treatment for 2 weeks (P<0, 05). Conclusion Salvia Miltiorrhiza could improve the clotting function in the hypertensive patients.%目的 观察丹参粉针剂对高血压患者凝血功能的影响.方法 入选120例初诊为轻中度原发性高血压患者,根据治疗方案分为常规降压治疗组(常规降压组)或丹参粉针剂治疗组(丹参治疗组),每组60例.丹参治疗组在常规降压治疗基础上加用丹参粉针剂400 mg加入5%葡萄糖注射液250 mL,1次/日,共2周.另入选50名同期年龄、性别相匹配之健康体检者为对照组.检测对照组观察前及两组高血压患者治疗前后凝血功能各项指标:纤维蛋白原(Fg)、血小板计数(PLT)、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤溶酶原激活物抑制物-1(PAI-1)、组织纤溶酶原激活物(t-PA)和D-二聚体(DD)的变化,并比较各组间的差异.结果 与对照组比较,高血压患者存在凝血功能紊乱现象,具体表现为TT、PT和APTT下降,Fg、PLT、PAI-1和DD升高,t-PA降低(均P<0.05).与治疗前比较,两组高血压患者治疗后凝血功能改善,表现为TT、PT和APTT延长,Fg、PLT、PAI-1和DD下降,t-PA升高;与常规降压组比较,丹参治疗组凝血功能各项指标改善程度更显著(P<0.05)rn丹参粉针剂有助于改善高血压患者的凝血功能障碍.