温肾通络汤对冠心病心绞痛患者血清M-CSF、hs-CRP、GMP-140的影响

摘要

Objective To study the effects of Wenshen Tongluo decoction(WTD) on serum macrophage colony stimulating factor (M - CSF), high sensitivity C - reactive protein (hs - CRP), and granules membrane protein - 140 (GMP - 140) in patients with coronary heart disease (CHD). Methods One hundred and twenty - eight CHD patients with yang - deficiency syndrome of heart - kidney complicated with stagnation of phlegm and blood stasis were randomly divided into two groups: Treatment group (n = 66) treated with WTD and control group (n=62) treated with Shexiang Baoxin pill for 2 weeks. The levels of serum M - CSF, hs - CRP and GMP - 140 were detected. Results After 2 weeks of treatment, the levels of serum M - CSF, hs - CRP, and GMP - 140 in both groups were all decreased significantly (P<0. 01). There were no significant differences in the levels of serum M - CSF, hs - CRP, GMP - 140 between two groups (P>0. 05). Conclusion WTD had effects on antagonizing inflammatory response of coronary artery, inhibiting activation of platelets, which might be one of the mechanisms for WTD to treat CHD with yang - deficiency syndrome of heart - kidney complicated with stagnation of phlegm and blood stasis.%目的 观察温肾通络汤对冠心病(CHD)心肾阳虚兼痰瘀内阻证患者冠状动脉炎症、血小板活化作用的影响.方法 将128例CHD心肾阳虚兼痰瘀内阻证患者随机分为两组,治疗组66例,口服温肾通络汤每次120 mL,每日2次,治疗2周.对照组62例,口服麝香保心丸,每次2粒,3次/日,治疗2周.分别于治疗前后采集空腹静脉血,测定血清巨噬细胞集落刺激因子(M-CSF)、超敏C反应蛋白(hs-CRP)、血小板α颗粒膜蛋白-140(GMP-140)水平.结果 两组治疗后血清M-CSF、hs-CRP、GMP-140水平均明显降低(P<0.01),组间治疗后比较差异无统计学意义(P>0.05).结论 温肾通络汤具有抑制冠状动脉炎症反应、抑制血小板活化作用,这可能是其治疗冠心病心肾阳虚兼痰瘀内阻证的机制之一.