芪参益气滴丸对慢性心力衰竭病人心率变异性及心功能的影响

摘要

目的：观察芪参益气滴丸对慢性心力衰竭病人心率变异性(HRV)及心功能的影响。方法选取102例除心脏瓣膜病以外的慢性力衰竭病人，随机分为单纯西药治疗的对照组(50例)和西药+芪参益气滴丸治疗的观察组(52例)，两组病人均坚持规范化服药治疗并随访观察6个月以上，观察两组病人治疗前后 HRV指标、左室射血分数(LVEF)、血液 B型利钠肽原(NT proBNP)浓度及6 min步行距离情况。结果两组病人经治疗后 HRV各时域指标及 LVEF、6 min步行距离均较治疗前提高，血 NT proBNP浓度较前降低，差异有统计学意义(P<0.05或P<0.01)；且与对照组相比观察组更为显著，除 LVEF外差异均有统计学意义(P<0.05)。结论芪参益气滴丸治疗慢性心力衰竭有助于进一步提高病人 HRV和改善心功能。%Objective To investigate the effects of Qishen Yiqi dropping pil (QYDP)on heart rate variability (HRV)and cardiac func-tion in patients with chronic heart failure (CHF).Methods One hundred and two patients with CHF excepting valvular heart disease were randomly divided into two groups:control group(n=50)treated with routine treatment,and treatment group(n=52)treated with routine treatment plus QYDP for 6 months.HRV and left ventricular ejection fraction (LVEF)were respectively measured with dy-namic electrocardiogram and echocardiography.The concentration of blood N terminal pro B type natriuretic peptide (NT pro BNP)and the distance of walking in 6 minutes were also respectively measured.Results After treatment,HRV and LVEF and the distance of walking in 6 minutes were improved and the concentration of NT proBNP in blood were lowered in two groups,which was better in treatment group than that in control group(P<0.05 or P<0.01).Conclusion QYDP can improve HRV and heart func-tion in patients with CHF.