康复训练联合阿托伐他汀对皮质下缺血性血管性痴呆病人认知功能及日常行为能力的影响

摘要

Objective To investigate the effects of rehabilitation training and atorvastatin on the cognitive function and daily behavior in patients with subcortical ischemic vascular dementia (SIVD).Methods Eighty-four patients with SIVD in our hospital from January 2012 to January 2014 were selected and randomly divided into two groups:control group (n =42) treated with donepezil hydrochloride tablets,and treatment group (n =42) treated with rehabilitation training and atorvastatin for 6 months.The scores of Brief Screening Scale for Dementia (BSSD),Information Memory Concentration Test (IMCT),Mini-Mental State Examination (MMSE),Activities of Daily Living Scale (ADL) were compared between two groups after 6 months.The patients were followed up for 1 year,and the recovery of clinical symptoms was observed.Results After 6 months of treatment,the scores of BSSD,IMCT,MMSE,ADL were significantly higher in treatment group than that in control group (P ＜0.05).After 1 years of follow-up,the recovery of clinical symptoms was better in treatment group than that in control group (P ＜0.05).Conclusion Rehabilitation training and atorvastatin can improve cognitive function and promote daily behavioral recovery in patients with SIVD.%目的 探讨康复训练联合阿托伐他汀对皮质下缺血性血管性痴呆(SIVD)病人认知功能及日常行为能力的影响.方法 选取我院2012年1月 2014年1月收治的SIVD病人84例,随机分为对照组和试验组,各42例.对照组采用盐酸多奈哌齐片治疗,试验组采用康复训练联合阿托伐他汀钙片治疗.比较两组病人治疗后6月痴呆简易筛查量表(BSSD),常识-记忆-注意测验(IMCT)以及简易智力状态检查(MMSE)的评分情况;比较两组6个月后日常生活能力量表(ADL);对病人1年后随访,比较两组临床症状的恢复情况.结果 治疗后6个月两组BSSD,IMCT,MMSE评分,对照组评分明显低于试验组,差异有统计学意义(P＜0.05).两组ADL评分,对照组明显低于试验组,差异有统计学意义(P＜0.05).随访1年试验组SIVD临床表现恢复较对照组好,两组差异有统计学意义(P＜0.05).结论 康复训练联合阿托伐他汀对SIVD病人的认知功能以及日常行为能力恢复有较好的效果.