温阳健心灵口服液治疗收缩功能不全性心力衰竭的临床研究

摘要

目的：了解温阳健心灵口服液 (WYJXLD)对收缩功能不全性心力衰竭(心衰)的疗效。方法：120例患者随机分2组，实验组给予WYJXLD、对照组给予开搏通治疗 ，疗 程均为2周。治疗前后均做多普勒超声心功能检查，部分患者做心钠素（ANF）、内皮素（ET ）和甲状腺激素（FT3、FT4）测定。治疗后按卫生部颁布的《中药新药治疗充血性心衰 指 导原则》进行疗效判定。结果：实验组总有效率67.8％，对照组60.0％ ，2组疗效经Ridit分析无显著差异。实验组治疗后心脏收缩功能指标〔如射血分数（EF）和 左心室后壁增厚率（ΔT％）〕明显增加（P<0.01）；另外，对伴舒张功能不全者， 其A ／E比值和A峰也明显下降（P<0.05）。上述心功能指标的改善均优于对照组（P均 <0 .05）。实验组心脏舒张功能的改善似从属于收缩功能的改善。在改善心功能的同时，实验 组ANF 和FT3也明显升高(P<0.05)。FT3的提高和心功能改善明显相关，而FT4的提高 和心功能改善的关系不大。结论：WYJXLD对收缩功能不全性心衰有良好的 近期疗效。%Objective:To study the curative effect of Wenyang Jianxin Ling drink(WYJXLD,温阳健心灵口服液) on deficient systolic heart failure.Methods:One hundred and twenty patients were randomly divided into two groups,they were given WYJXLD(trial group) or captopril(control group) respectively for 2 weeks.The cardiac function was evaluated by Doppler echocardi ography in all pa tients and the levels of atrial natriuretic factor(ANF),endoth elin(ET) and free triiodothyronine(FT3)，free thyroxine(FT4) before and afte r t reatment were measured in partial patients separately.The curative effect was j udged by the 《Guideprinciple of Traditional Chinese Medicine Treati ng Congestive Heart Failure》 published by the Public Health Department.Results:Two groups had no difference in effective rate by Radit analyse (67.8% vs.60. 0%).The indexes about systolic function such as ejection fraction(EF) and the t h ickening rate of left ventricular posterior wall were significantly increased in trial group(P<0.01).The A/E ratio and peak Awave were decr eased obviously in cases who had diastolic heart failure simultaneously in trial group (P<0.05).The improvement of abovementioned cardiac function indexes in trial group were superior to those in control group (P< 0.05).The improvement of the diastolic function seemed to subordinate to the improveme nt of systolic function. With the improvements of cardiac functions the ANF, FT ３ and FT４ were obviously increased in trial group.Regarding the thyroid h ormone the increase in FT３ was markedly related to the improvement of cardiac function but the increase in FT４ was not.Conclusions:WYJXLD has good shortterm curative effect on systolic heart failure in the near future.