红景天对急性冠脉综合征患者经皮冠状动脉介入治疗后血清肿瘤坏死因子-α的影响

摘要

Objective To explore the effect of rhndiola on serum tumor necrosis factor-α (TNI—α) m patients with acute coronary syndrome ( ACS) after percutaneous coronary intervention ( PCI) . Methods A prospective study was conducted. Sixty-four patients with ACS after P( A were randomly divided into treatment group (34 cases) and control group (30 cases)- Routine drugs including aspirin, clopidogrel, metoprolol, isosorhide, dinitrate and so on were given to all the patients in the two groups. Additionally, the treatment group was treated by Rhoriiola capsule 0.56 g once, 3 times a day for 90 days. Serum concentration of TNI—a was measured by enzyme-linked immunosorbent assay ( KLISA) before operation and [ day. 1 month and 3 months after operation. Results The serum TNI—α (μg/L.) levels in patients of treatment group and control group were not significantly different before PCI (262.33±69.35 vs. 255.63±67.91, P＞＞0.05), the serum TNI—a levels were sharply increased 1 day after PCI compared with those before PCI (389.7] ±76.15,347.48±55.07. P＜0.01 ) , the levels of 1 month after PCI (34.96± 18.27, 25.76± 14.48) and 3 months after PCI (17.30±7.64,10.60±6.55) were obviously decreased compared with those of 1 day after PCI (all P＜0.01) ; the serum TNI-α levels of 1 day, I month and 3 months after PCI in treatment group were apparently lower than those in control group (1 day post-PCI : 347.48±55.07 vs. 389.71 ±76.15, 1 month post-PCI: 25.76± 14.48 vs. 34.96±18.27, 3 months post-PCI : 10.60±6.55 vs. 17.30±7.64, all P＜ 0.01) . Conclusion Rhodiola can significantly reduce the serum TNI—α level after PCI, thus it possesses the action of inhibiting the inflammatory response to protect myocardium in patients with acute coronary infarction after PCI.%目的 观察红景天对急性冠脉综合征(ACS )患者经皮冠状动脉介入治疗(PCI )后肿瘤坏死因子-α(TNF-α)的影响.方法 采用前瞻性研究方法,将64 例ACS 的PCI 术后患者按随机数字表法分为治疗组(34 例)和对照组(30 例).两组患者均给予拜阿司匹林、氯吡格雷、阿托伐他汀、消心痛等常规药物治疗;疗组在常规治疗基础上加用红景天胶囊0.56 g,每日3 次,疗程为90 d.用酶联免疫吸附试验(ELISA )测定术治前和术后1d 、1 个月、3 个月患者血清TNF-α的含量.结果 对照组和治疗组患者术前血清TNF-α(μg/L )水平比较差异无统计学意义(255.63±67.97 比262.33±69.35,P＞0.05),术后1d 血清TNF-α水平(389.71±76.15 、347.48±55.07 )均较术前明显升高(均P＜0.01)术后1 个月(34.96±18.27 、25.76±14.48)、3 个月(17.30±7.64 、10.60±6.55 )均较术后1d 明显降低(均P＜0.01.治疗组术后1d 、1 个月、3 个月血清TNF-α水平较对照组显著降低(术后1d:347.48±55.07 比389.71±76.15,术后1 个月:25.76±14.48 比34.96±18.27,术后3 个月:),10.60±6.55 比17.30±7.64,均P＜0.01).结论 红景天可以降低ACS PCI 术后患者血清TNF-α水平,具有抑制PCI 术后患者炎症反应的作用.