Objective To investigate the clinical efficacy of hydrocortisone sodium succinate for treatment of septic shock patients and their prognoses. Methods A prospective case control study was conducted. 49 patients with septic shock in the Department of Emergency of the First Affiliated Hospital of Xi'an Jiaotong University were enrolled from January 2010 to January 2012,and the patients were sequentially divided into two groups,the treatment group(24 cases)and the control group(25 cases),by the difference in odd or even number. All patients in the two groups accepted the conventional treatment. The treatment group additionally received hydrocortisone sodium succinate injection 200 mg,once a day for 5 days. The levels of serum procalcitonin(PCT),C-reactive protein(CRP)were measured in all the patients before treatment and 24 hours,72 hours and 7 days after treatment. The mortalities were compared in 14 days between the two groups. Results The levels of PCT,CRP before and 24 hours after treatment were not statistically significant different from those of pre-treatment in two groups(all P>0.05). PCT and CRP were decreased at 72 hours and 7 days after treatment in the two groups,and on the 7th day the decline was more significant, and compared with the control group,the levels of PCT and CRP in treatment group were reduced more markedly at 72 hours and on the 7th day〔PCT(μg/L):72 hours 9.73±2.10 vs. 12.36±2.56,7 days 5.33±2.05 vs. 8.76±1.78;CRP(μg/L):72 hours 69.12±13.61 vs. 109.68±16.16,7 days 20.16±9.64 vs. 42.32±13.16,all P<0.05〕. But the mortality in 14 days was not statistically significant different between control group and treatment group(52.0%vs. 45.8%,P>0.05). Conclusion The treatment with hydrocortisone sodium succinate can reduce the inflammation of patients with septic shock,thus it has clinical value in the improvement of the disease situation.%目的：探讨氢化可的松琥珀酸钠对脓毒性休克患者疗效及预后的影响。方法采用前瞻性研究方法，将2010年1月至2012年1月西安交通大学医学院第一附属医院急诊科收治的49例脓毒性休克患者，按入院顺序的奇偶数分为治疗组24例与对照组25例。两组均给予常规治疗，治疗组在常规治疗基础上加用氢化可的松琥珀酸钠200 mg，每日1次，连用5 d。观察治疗前及治疗后24 h、72 h、7 d两组血清降钙素原（PCT）和C-反应蛋白（CRP）水平；并比较两组14 d病死率。结果治疗前及治疗后24 h，两组PCT、CRP比较差异均无统计学意义（均P＞0.05），治疗后72 h、7 d两组PCT和CRP水平均较治疗前明显下降，以7 d下降最显著；且治疗组较对照组下降更明显〔PCT（μg/L）：治疗后72 h 9.73±2.10比12.36±2.56，治疗后7 d 5.33±2.05比8.76±1.78；CRP（μg/L）：治疗后72 h 69.12±13.61比109.68±16.16，治疗后7 d 20.16±9.64比42.32±13.16，均P＜0.05〕。但对照组和治疗组患者14 d病死率比较差异无统计学意义（52.0%比45.8%，P＞0.05）。结论氢化可的松琥珀酸钠能减轻脓毒性休克患者的炎症反应，对改善病情有一定临床价值。
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