氟尿苷-层状双金属氢氧化物纳米杂化物制备及表征

摘要

采用共沉淀法将抗癌药物氟尿苷插入Mg-Al层状双金属氢氧化物(LDHs)的层间,合成了氟尿苷-LDHs纳米杂化物.依据氟尿苷分子大小和杂化物通道高度推测,氟尿苷分子是以长轴垂直或略倾斜于LDH8层片在LDHs层间呈双层排列.分别在pH=4.8和7.2的介质中研究了药物释放动力学,表明符合准二级动力学方程;释放速率随载药量增大而降低;氟尿苷-LDHs纳米杂化物具有良好的缓释效果.%The intercalation of Floxuridine into layered double hydroxide(LDHs)was used via coprecipitation method to obtain Floxuridine-LDHs nanohybrids.According to the gallery height of Floxuridine-LDHs and size of floxuridine molecule,a possible morphology of floxuridine molecules in the gallery of LDHs is suggested that floxuridine molecules ale intercalated into the gallery of LDHs with a vertical-arranged bilayer along the long axis.The release kinetics of floxuridine from the nanohybrids WaS investigated at pH value of 4.8 and 7.2,respectively.It is found that the nanohybrids can control the release of floxuridine,and the in vitro drug release from the nanohybrids is remarkably lower than that from the corresponding physical mixture.The release rate of floxuridine decreases with the increase of floxuridine loading and the whole release process may fit to the pseudo-second-order release kinetics.