不同模拟体液中水化硅酸三钙固化体的体外生物活性行为

摘要

研究水了化硅酸三钙(Ca3SiO5,C3S)固化体的体外生物活性行为.结果表明,干C3S固化体中含有23.97wt％的Ca(OH)2,Ca(OH)2的溶解导致模拟体液(Simulated Body Fluids,SBF)的pH值上升;磷灰石颗粒优先诱导沉积于C3S固化体表面,随后碳酸钙和磷灰石颗粒共同沉积于C3S固化体表面;HCO3-是SBF模拟体液内主要的缓冲离子;Ca(OH)2碳化和CaCO3沉积主要导致SBF的pH值下降.由于离子交换作用的减弱,C3S固化体表面最终被磷灰石完全覆盖,磷灰石的沉积促使SBF的pH值进一步降低.因此,对于C3S和其衍生材料的体外生物活性和生物相容性必须考虑到HCO3-在体内的实际含量和行为.%The in vitro bioactive behaviors of hydrated tricalcium silicate (Ca3SiO5,C3S) paste were studied.The results show that dry hydrated C3S paste contains about 23.97wt％ Ca(OH)2,and the dissolution of Ca(OH)2 results in increased pH value of simulated body fluid (SBF).Apatite particles are firstly induced to deposit on hydrated C3S paste surface.Then,hydrated C3S paste surface is co-deposited with CaCO3 and apatite particles.HCO3 is the principal buffer system of SBF,and the carbonation of Ca(OH)2 and deposition of CaCO3 mainly contribute to the decreasing of pH value.As a result of lower ion exchanges,hydrated C3S paste surface is finally deposited with apatite.The deposition of apatite contributes to the further decreasing of pH value.The in vitro bioactivity and further biocompatibility evaluations of C3S and C3S devised materials must be improved by considering the concentration and behavior of HCO3-in living body.