4-甲基-1,2,3-噻二唑-5-甲酸构筑的锌配合物的合成、晶体结构及与DNA作用

摘要

由4-甲基-1,2,3-噻二唑-5-甲酸(HMTC,C4H4N2O2S)分别和1,3-双(4-吡啶基)-丙烷(bpp)、菲咯啉(phen)合成了2个锌配合物[Zn(MTC)2(bpp)]n(1)和[Zn(MTC)(phen)(H2O)2](MTC) (2).用元素分析、红外光谱、粉末X射线衍射、热重分析对配合物进行了表征,并通过单晶X射线衍射测定了配合物的晶体结构.结果表明:配合物1是二维网状结构,属于单斜晶系,P21/c空间群,中心金属锌(Ⅱ)离子的配位构型是扭曲的四面体结构.配合物2是二维层状结构,属于三斜晶系,P(1)空间群,中心金属锌(Ⅱ)离子的配位构型是变形的三角双锥结构.用溴化乙锭荧光探针法测定了配体和配合物对EB-DNA复合体系相互作用,实验结果显示无论配体还是配合物均能使EB-DNA复合体系发生不同程度的荧光猝灭,且配合物的作用强度远大于配体.%Two new zinc complexes [Zn(MTC)2(bpp)]n (1) and [Zn(MTC)(phen)(H2O)2](MTC) (2) (HMTC=4-methyl-1,2,3-thiadiazol-5-carboxylic,C4H4N2O2S;bpp=1,3-bis(4-pyridyl) propane;phen=1-10-phenanthroline) have been synthesized and characterized by single crystal X-ray diffraction,elemental analysis,IR spectra,PXRD and TG.The single crystal X-ray diffraction reveals that the complex 1 is two-dimensional network structure and crystallized in monoclinic with space group P21/c.Central Zn2+ is four-coordinated forming a distorted tetrahedron coordination geometry.The complex 2 is two-dimensional layered structure and crystallized in triclinic with space group P1.Central Zn2+ is five-coordinated forming a distorted trigonal bipyramid coordination geometry.In addition,the interaction of complexes and ligand with EB-DNA were also studied by EtBr fluorescence probe.The interaction of complexes with DNA is stronger than ligand.CCDC:1564691,1;1564890,2.