不同组方的速效祛风止动方对抽动障碍大鼠行为的影响

摘要

Objective To approach the influence of two kinds of Immediate Effect Qufeng Zhidong Recipe on tic disorder rat model behavior, by applying apomorphine (APO)-induced tic disorder rat model.Methods Fifty SD rats were randomly divided to normal group, model group, Immediate Effect Qufeng Zhidong Recipe 1 (IEQZR-1) group, Immediate Effect Qufeng Zhidong Recipe 2 (IEQZR-2) group and Qufeng Zhidong Recipe (QZR) group, 10 rarts in each group.After one and two weeks' therapy, the improvement degrees of stereotyped behavior and the open-field test including the number of passing-panel, straightening, groomming and dejects pill were observed.Results There were no difference in the weights and laboratory examinations of the five groups.The effect of IEQZR- 1 and IEQZR-2 groups were better than that of QZR group at the aspect of tachy-decreasing the tic disorder rats' stereotyped behavior (P＜0.05).The therapy of IEQZR-1 and IEQZR-2 group were better than that of QZR group at the aspect of improving the number of passing-panel, straightening, gromming and dejecta pill.Conclusion IEQZR-1 and IEQZR-2 can improve the activity level of the tic disorder rat induced by APO more quickly and reinforce the animal's ability of adapt ion, with no side effects.%目的 应用阿扑吗啡(APO)诱导的抽动障碍大鼠模型,探讨不同组方的速效祛风止动方对抽动障碍大鼠行为的影响.方法 采用随机抽签分组方法,将50只雄性SD大鼠分为正常组,模型组、速效祛风止动1号方(速效1号)组、速效祛风止动2号方(速效2号)组和祛风止动方组,每组10只,分别给予相应药物,观察各组大鼠治疗1周和2周后刻板行为和开野实验的穿越格子数、直立次数、理毛次数、粪便粒数的改善程度.结果 各组大鼠的体重、实验室检查比较,差异无统计学意义;速效1号组、速效2号组在快速减少抽动大鼠的刻板行为方面优于祛风止动组(P＜0.05);速效1号组、速效2号组在改善穿越格子数、理毛次数、直立次数、粪便粒数方面优于祛风止动组(P＜0.05).结论 速效1号方、速效2号方能较快改善APO诱导的抽动大鼠的活动水平,增强动物的适应力,且无毒副作用.