Objective To investigate the anti-rotavirus effect of Gegen Qinlian decoction on rotavirus (RV)-inducing diarrhea neonatal mice model, and provide evidences for pharmacological and pharmacodynamic studies. Methods Neonatal diarrhea mice model of Kunming family infected with RV-Wa was developed. Symptom, diarrhea ratio and severity level, histological changes of neonatal mice’s small intestine and lung was assessed after Gegen Qinlian decoction (0.78 g/kg) treatment. Results Diarrhea ratio, diarrhea severity level, histological changes of neonatal mice’s small intestine and lung were obviously decreased after Gegen Qinlian decoction (0.78 g/kg) treatment. Conclusion Gegen Qinlian decoction has anti-rotavirus effect on RV induced diarrhea.%目的观察葛根芩连方对Wa株轮状病毒感染乳鼠腹泻的治疗作用,为深入研究开发葛根芩连方提供实验依据。方法建立Wa株轮状病毒感染昆明小鼠乳鼠腹泻模型和空白对照模型,以葛根芩连方提取物0.78 g/kg进行干预治疗,比较用药前后Wa株轮状病毒感染乳鼠的体征、腹泻率、腹泻程度、小肠及肺的病理形态学等指标变化。结果葛根芩连方提取物0.78 g/kg能够降低乳鼠的腹泻率,减轻腹泻程度,改善感染乳鼠体征及小肠病理形态学变化。结论葛根芩连方具有抗Wa株轮状病毒作用。
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