PGⅠ、PGⅡ、G-17和Hp IgG抗体筛查慢性萎缩性胃炎和胃癌的价值

摘要

Objective:To analyze the value of pepsinⅠ( PGⅠ) , pepsinⅡ( PGⅡ) , gastrin-17 ( G-17 ) diagnostic and Helicobacter pylori( Hp IgG) antibody in screening chronic atrophic gastritis and gastric cancer.Methods:90 patients with an upset stomach in our hospital from May 2014 to May 2015 were selected for the study, according to the pathological diagnosis which were divided into normal control group( including chronic non-atrophic gastritis) ,chronic atrophic gastritis group and gastric cancer,30 cases in each group.The level of PGⅠ, PGⅡ, G-17 and Hp IgG antibody positive rate in the three groups of patients were compared.Results:The level of PGⅠ,PGⅡin gastric cancer patients were lower than the control group and chronic atrophic gastritis group.And the index of chronic atrophic gastritis patients were lower than control group.The level of G-17 in gastric cancer group was higher than chronic atrophic gastritis group and the control group, and chronic atrophic gastritis group and the control group had no significant difference.The Hp IgG antibody positive rate in gastric cancer group was significantly higher than other two grups.The level of PGⅠand PGⅡin Hp-infected patients were lower than uninfected Hp patients,and the level of G-17 was higher than uninfected Hp patients.The level of PGⅠ, PGⅡ were significantly negatively correlated with age, pathological stage and metastasis, and positive related with the degree of differentiation;but the level of G-17 and Hp IgG antibody rate were positive related with age,pathological stage and metastasis, and negatively correlated with the degree of differentiation.Conclusion: PGⅠ, PGⅡ and Hp IgG antibody screening have a good diagnostic value in chronic atrophic gastritis and gastric cancer,and better diagnostic value of gastric cancer,G-17 diagnostic value of gastric cancer is much better than the chronic atrophic gastritis;and the level of PGⅠ,PGⅡ,G-17 and IgG antibody positive rate are closely related to the clinicopathological features of gastric cancer patients.%目的：分析胃蛋白酶Ⅰ（ PGⅠ）、胃蛋白酶Ⅱ（ PGⅡ）、胃泌素-17（ G-17）和幽门螺杆菌（ Hp IgG）抗体筛查对慢性萎缩性胃炎和胃癌的诊断价值。方法：以2014年5月-2015年5月胃部不适来我院就诊的90例患者为研究对象，根据病理诊断结果分为正常对照组（包括慢性非萎缩性胃炎）、慢性萎缩性胃炎组和胃癌组，每组各30例，比较三组患者PGⅠ、PGⅡ、G-17水平及Hp IgG抗体阳性检出率。结果：胃癌组患者的PGⅠ、PGⅡ水平低于对照组和慢性萎缩性胃炎组，且慢性萎缩性胃炎组患者上述指标低于对照组；胃癌组G-17水平高于慢性萎缩性胃炎组和对照组，而慢性萎缩性胃炎组和对照组无明显差异；三组间Hp IgG抗体阳性率有明显差别，胃癌组显著高于对照组和慢性萎缩性胃炎组；Hp感染患者的PGⅠ和PGⅡ水平低于未感染Hp者，而G-17水平高于未感染Hp者；胃癌患者的PGⅠ、PGⅡ水平与年龄、病理分期和转移显著负相关，与分化程度显著正相关，而G-17水平及Hp IgG抗体阳性率与年龄、病理分期和转移显著正相关，而与分化程度显著负相关。结论：PGⅠ、PGⅡ和Hp IgG抗体筛查对慢性萎缩性胃炎和胃癌均有很好的诊断价值，而对胃癌的诊断价值更好，G-17对胃癌的诊断价值远远好于慢性萎缩性胃炎；且PGⅠ、PGⅡ、G-17水平及Hp IgG抗体阳性检出率与胃癌患者的临床病理特征密切相关。