风湿性疾病血清维生素A水平下降

摘要

目的:研究白塞病及常见免疫风湿性疾病血清维生素A(sVit A)水平.方法:化学发光法测得白塞病(BD,包括眼BD、肠BD、血管BD等3种罕见亚型)、类风湿关节炎(RA)、系统性红斑狼疮(SLE)、强直性脊柱炎(AS)、原发干燥综合征(pSS)和成年发病Still病(AOSD)等6种疾病sVit A水平,并与50例健康对照组(HC)进行比较,其中针对RA、SLE、AS和pSS对HC进行配对设计后比较.结果:纳入的各种风湿性疾病符合相应的流行病学特点;眼BD、肠BD、血管BD及皮肤黏膜型BD sVit A水平均低于健康人群(P<0.05),组间无差异;RA、SLE、AS、pSS和AOSD sVit A水平均低于健康人群(P<0.05).结论:sVit A浓度下降可能是多种免疫风湿性疾病的共同机制.%Objective:To investigate the serum Vitamin A(sVit A) levels in Behcet′s disease(BD)and other rheumatological diseases.Methods: sVit A concentration was measured in BD(including 3 subtypes of eye BD,intestinal BD,and vascular BD),rheumatoid arthritis(RA),systemic lupus erythematosus(SLE),ankylosing spondylitis(AS),primary Sjogren′s syndrome(pSS) and adult onset Still disease(AOSD)and compared with healthy controls(HC).Results: The patients enrolled in this study was according with the epidemiological features;BD patients including its subtypes of eye BD,intestinal BD,and vascular BD patients all had a lower concentration of sVit A than HC(P<0.05),no statistical differences between the subtypes;RA,SLE,AS,pSS and AOSD had a lower concentration of sVit A than HC(P<0.05).Conclusion: Decreased serum Vit A levels might account for a common pathogenesis of various rheumatic diseases.