女性尖锐湿疣患者合并解脲支原体感染的临床分析及治疗研究

摘要

Objectives:To conduct clinical analysis and treatment of female patients with genital warts and UU infection.Method:1 28 female patients with genital warts,from June 201 1 to May 201 2,were chosen as the observation group.80 patients with no genital warts UU in the same period were selected as the control group.The general data of the two groups had no significant difference (P>0. 05 ).The situation of patients with genital warts infection,the positive rate of combined UU and tolerance to antibiotics were studied.Results:The clinical analysis of the results showed that positive rate of genital warts combined with mycoplasma infection was as high as 1 9. 5%. From the aspect of age distribution of coinfected patients with genital warts,patients of 20~45 years old accounted for most of the positive cases.UU detection rate of observation group was 1 9. 5%,and UU detection rate of the con-trol group was 8. 8%,with statistically significant difference (P<0. 05 );UU tolerance to ciprofloxacin and ofloxa-cin was high,81 . 25%and 68. 75%respectively.Tolerance of Azithromycin,clarithromycin and roxithromycin was around 20%,1 8. 75%,21 . 88% and 1 8. 75%respectively.The tolerance to doxycycline was the lowest,6. 25%. Conclusion:In summary,through the research on the situation of female genital warts infection,UU combined posi-tive rate and the tolerance of UU to commonly used antibiotics,it is concluded that female patients with genital warts are often combined with UU infection so the treatment of genital warts with UU infection should pay attention to the de-tection of UU.Due to the tolerance of UU to commonly used antibiotics,in clinic we should be flexible according to the pathogen tolerance and reasonably choose antibiotics to minimize the occurrence of drug-resistant cases.%目的：女性尖锐湿疣患者合并解脲支原体感染的发病率及支原体耐药性的研究。方法：本研究选择的对象为2011年6月至2012年5月接受治疗的128例女性尖锐湿疣患者，将其作为观察组，另外选取同期接受体检的80例无尖锐湿疣的患者，将其作为对照组，两组患者的一般资料比较无显著性差异（P＞0．05），对尖锐湿疣患者合并感染的情况、合并解脲支原体的阳性检出率以及解脲支原体对常用抗生素的耐药性进行研究。结果：从尖锐湿疣患者的合并感染的临床分析中可以看出，尖锐湿疣合并支原体的感染的阳性率较高，阳性率为19．5％，从尖锐湿疣患者的合并感染的年龄分布来看，20～45岁患者占了阳性病例的大部分，该年龄段是尖锐湿疣患者合并感染的多发年龄；观察组检出解脲支原体发病率为19．5％，对照组检出解脲支原体的发病率为8．8％，两组患者的解脲支原体发病率进行比较有显著性差异（P＜0．05）；解脲支原体对环丙沙星以及氧氟沙星的耐药性较高，分别为81．25％与68．75％。对阿奇霉素、克拉霉素、罗红霉素的耐用性在20％左右，分别为18．75％、21 ．88％、18．75％，对强力霉素的耐药性最低，耐药率为6．25％。结论：女性尖锐湿疣患者往往合并解脲支原体的感染，因此在治疗尖锐湿疣的过程中要注意对解脲支原体的检测，从解脲支原体对常用抗生素的耐药性来看，在临床上应根据致病菌的耐药情况灵活掌握，合理选择抗生素，尽量减少耐药情况的发生。