玉屏风颗粒对复发性生殖器疱疹患者血清IFN-γ、IL-4水平的影响研究

摘要

目的:研究玉屏风颗粒对复发性生殖器疱疹患者血清干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)水平的影响.方法:选取从2015年1月至2016年1月在我院就诊的100例复发性生殖器疱疹患者,将所有患者随机均分为治疗组1和治疗组2(各50例),其中治疗组1口服泛昔洛韦片,治疗组2冲服玉屏风颗粒,并从门诊体检处选取50例正常人群作为正常组,对比治疗组1、治疗组2治疗前后血清IFN-”IL-4水平.结果:两治疗组患者在治疗前后血清IFN-γ、IL-4水平均有明显的变化,差异具有统计学意义(P＜0.05);治疗组2治疗前后的变化明显大于治疗组1,差异具有统计学意义(P＜0.05).结论:玉屏风颗粒在治疗复发性生殖器疱疹患者过程中能明显升高血清IFN-γ、降低IL-4水平.%Objectives:To study the effect of Yupingfeng Granules on serum interferon gamma (IFN-γ) and interleukin-4 (IL-4) in patients with recurrent genital herpes.Methods:100 patients with recurrent genital herpes in our hospital from January 2014 to December 2015 were selected as treatment group and divided into treatment group 1 and group 2 randomly,each of 50 cases.Another 50 health people were selected as control group.Treatment group 1 and group 2 was given yupingfeng Granule and famciclovir (FCV) for treatment respectively.The serum levels of IFN-γ and IL-4 in treatment group 1 and group 2 was compared between before and after treatment.Results:The serum levels of IFN-γ and IL-4 in the two treatment group were significantly changed after treatment,with statistically significant difference (P ＜ 0.05).The change in treatment group 2 between before and after treatment was significantly higher than that of the control group 1,with statistically significant difference (P ＜0.05).Conclusion:Yupingfeng Granule in the treatment of patients with recurrent genital herpes can significantly increase the serum IFN-γ and reduce the serum IL-4.