妊娠期血红蛋白浓度与妊娠结局相关性分析

摘要

目的:分析研究妊娠期母体高浓度血红蛋白与妊娠结局的相关性.方法:在2013年12月至2015年12月两年间来恩施土家族苗族自治州中心医院和湖北省妇幼保健院进行分娩的孕妇中,选取妊娠期在28周以上的单胎妊娠孕妇1374例.按照孕妇体内血红蛋白浓度的差异分为四组:血红蛋白浓度在75％以上者作为1组,50％～75％之间为2组,3组25％～50％,4组浓度在25％以下.统计分析血红蛋白浓度差异与妊娠结果的相关性.结果:通过对1374例研究对象记录的分析,四组孕妇孕早期血红蛋白浓度与妊娠结局无相关性(P＞0.05).孕中晚期四组研究对象妊娠结局差异明显(P＜0.05),1、2组妊娠结局出现了更多不良情况.孕中期四组血红蛋白浓度分别为138g/L以上、130～ 138 g/L、123～ 129 g/L、123 g/L以下.孕晚期四组血红蛋白浓度分别为135 g/L以上、127～134 g/L、119～ 126 g/L以上、119 g/L以下.孕中期血液粘度＜4.50与≥4.50两组间无显著差异(P＞0.05).与正常妊娠相比,孕晚期高血液粘度所造成的不良妊娠结局显而易见(P＜0.05).结论:妊娠期母体内高浓度血红蛋白是造成不良妊娠结局的风险因素,应引起相关工作者与研究者的重视,及早记录、及早举措,保证母婴远离病患.%Objectives:To analyze of the relationship between hemoglobin concentration in pregnancy and pregnancy outcome.Methods:1374 pregnant women with more than 28 weeks pregnant singleton pregnancies in our hospital from December 2013 to December 2015 were selected.According to differences in hemoglobin concentration,pregnant women were divided into four groups,group Ⅰ (hemoglobin concentration above 75％),group Ⅱ (50％ ～75％),group Ⅲ (25％ ～50％) and group V (less than 25 ％).The relationship between hemoglobin concentration in pregnancy and pregnancy outcome was analyzed.Results:The hemoglobin concentration and the pregnancy outcome had no correlation in four groups of pregnant women in early pregnancy (P ＞ 0.05).Pregnancy outcomes four groups in middle and late pregnancy were significantly different (P ＜ 0.05).Pregnancy outcome of group Ⅰ and group Ⅱ had more unfavorable situation.Hemoglobin concentration of four groups in second trimester were 138g / L or more,130 ～ 138 g / L,123 ～ 129 g / L and 123 g / L or less.Hemoglobin concentration of four groups in late pregnancy were 135 g / L or more,127 ～ 134 g / L,119 ～ 126 g / L or more and 119 g / L or less.Compared with normal pregnancy,adverse pregnancy outcomes and high blood viscosity in third trimester were obviously correlated (P ＜ 0.05).Conclusion:The high concentration of hemoglobin during pregnancy is a risk factor for adverse pregnancy outcomes,which should be paid attention by relevant workers and researchers.Early records and early intervention are the way to ensure the health of maternal and newborns.