微波辐射对男性生殖系统及生殖内分泌影响的META分析

摘要

目的:系统评价微波辐射对男性生殖系统和生殖内分泌的影响.方法:计算机检索CNKI、VIP、万方数据库、Pubmed、Speringer、Web of Science数据库,两名研究者根据纳入排除标准独立筛选文献,对7篇有关微波辐射对男性生殖系统影响的病例对照研究进行综合分析,应用Revman5.3进行Meta分析.结果:与对照组比较,微波辐射作业的男性A级精子活力的加权均数差值为-18.97％(95％ CI:-33.46％,-4.47％),差异性显著;B级精子活力的加权均数差值为-9.24％(95％ CI:-14.46％,-4.01％);C级精子活力的加权均数差值为OR=-1.68％ (95％ CI:0.57％,2.80％);D级精子活力的加权均数差值为20.10％ (95％ CI:11.42％,28.77％);辐射组精液密度的加权均数差值为-10.77×109/L(95％ CI:-16.99×109,-4.55×109)精液密度显著降低;孕激素的加权均数差值为0.25pg/mL(95％ CI:0.08,0.41),辐射组孕激素较对照组组显著性升高;而对照组与辐射组之间的精液量、精子存活率、T、FSH、LH、PRL、E2无统计学差异.结论:微波辐射使男性精液质量低下,扰乱生殖内分泌,降低男性生育能力.%Objectives:To systematically review the effect of the microwave radiation on the reproductive system and the reproductive endocrine system.Methods:By retrieving the literatures on effect of the microwave radiation on the reproductive system and the endocrine system through the CNKI,VIP,Wanfang,Pubmed,Speringer and SCI,the trials in 7 papers were selected according to the inclusive and exclusive criteria.The quality of the lit eratures was assessed and the data information was extracted.The data was analyzed by the Revman 5.3 software.Results:Compared with the control group,the weighted mean difference (WMD) of sperm motility in A-level sperm was-18.97％ (95％ CI:-33.46％,-4.47％),with significant difference the WMD of B-level sperm was-9.24％ (95％CI:-14.46％,-4.01％);the WMD of C-level sperm was-1.68％ (95％CI:0.57％,2.80％),and the WMD of D-level sperm was 20.10％ (95％ CI:11.42％,28.77％).The WMD of sperm concentration in the radiation group was-10.77 × 109/L (95％ CI:-16.99 × 109,-4.55 × 109) and the WMD of progestin was 0.25pg/ml (95％CI:0.08,0.41),significantly higher than the control group.Difference in the semen volume,sperm survival rate and T,FSH,LH,PRL and E2 was not statistically significant.Conclusion:Microwave radiation not only reduces human semen quality but also disturb the endocrine system,hereby reducing male fertility.