中性粒细胞明胶酶相关载脂蛋白、降钙素、C-反应蛋白与急性缺血性脑卒中的相关性研究

摘要

目的 探讨中性粒细胞明胶酶相关载脂蛋白(N-gal)、降钙素(HCT)及C-反应蛋白(CRP)与急性缺血性脑卒中的相关性,并通过上述指标评估缺血性脑卒中预后,发掘其临床应用价值.方法 前瞻性收集53 例急性脑梗死患者为观察组、另入选53 名同期健康志愿者为对照组,抽取观察组入院24 h内、入院1 周空腹血标本,以及对照组空腹血标本,分别进行N-gal、HCT及CRP检测,并对观察组入院24 h内及入院1 周的NIHSS评分进行比较.结果 观察组N-gal值、CRP值显著高于对照组(P＜0.05),观察组HCT值与对照组相比,差异无统计学意义(P＞0.05);观察组入院24 h内N-gal值、CRP值显著高于入院1 周相应值(P＜0.05),入院24 h内HCT值与入院1 周相应值相比,差异无统计学意义(P＞0.05);观察组入院24 h内和入院1 周N-gal差值与入院24 h内和入院1 周NIHSS评分差值呈负相关(r﹦－0.289,P＜0.05), 观察组入院24 h内和入院1 周HCT差值、CRP差值与入院24 h内和入院1 周NIHSS评分差值无相关性(P＞0.05).结论 N-gal、CRP与急性缺血性脑卒中相关,N-gal对急性缺血性脑卒中的诊断、预后评估有重要价值.%Objective To study the correlation between neutrophil gelatinase-associated lipocalin (N-gal), calcitonin (HCT) and C-reactive protein (CRP) with acute ischemic stroke, to evaluate the prognosis of ischemic stroke by the above indicators, and discover the clinical application value. Methods 53 patients with acute cerebral infarction were collected as observation group and 53 healthy volunteers in the same period as control group. We collected the fasting blood samples of observation group within 24 hours in hospital and one week later, and the fasting blood samples of control group, to detect the level of N-gal, HCT and CRP separately. We assessed the NIHSS scores within 24 hours in hospital and one week later to the observation group, and to compare with them. Results The N-gal value and CRP value of the observation group were significantly higher than those of the control group (P＜0.05), no statistical difference was found in the HCT value on the observation group and the control group (P＞0.05). The N-gal value and CRP value of patients with acute ischemic stroke within 24 hours in hospital were significantly higher than those one week later (P＜0.05), no statistical difference was found in the HCT values on patients with acute ischemic stroke within 24 hours in hospital and one week later (P＞0.05). In the observation group, the N-gal difference within 24 hours in hospital and one week later was negatively correlated with the difference in NIHSS scores within 24 hours in hospital and one week later ( r﹦－0.289, P＜0.05), no statistical difference in the observation group was found between the difference of HCT and CRP within 24 hours in hospital and one week later and the difference of NIHSS score within 24 hours in hospital and one week later (P＞0.05). Conclusion N-gal and CRP are associated with acute ischemic stroke. N-gal is of great value in the diagnosis and prognosis assessment of acute ischemic stroke.