高血压患者降压药选择偏好性研究

摘要

目的 探讨药物的属性对高血压患者选择降压药偏好的影响以及高血压患者对苯磺酸左旋氨氯地平片降压药的偏好情况.方法 选择2018年4月—2018年6月,苏州市五家医院1 467 例服降压药的高血压患者,采用离散选择实验设计18个药物选择集,调查高血压患者选择药物的情况,用条件Logistic回归模型分析六种药物属性对患者选择药物偏好的影响.结果 纳入研究的六个药物属性对高血压患者的药物选择偏好都有影响(均P＜0.05),影响作用比较大的三个因素依次为心脑肾保护效果、降压效果和不良反应.而降压速度、每日费用和作用时间的影响较小.结论 与三种对照药物相比,苯磺酸左旋氨氯地平片降压药都有更大的可能性被选择.该研究结果为降压药的研发以及患者选择降压药提供一定的参考依据.%Objective To investigate the influence of drug properties on the selection preference of antihypertensive drugs in patients with hypertension and the preference of Levamlodipine Besylate Tablets in patients with hypertension. Methods FromApril 2018 to June 2018, 1 467 hypertensive patients taking antihypertensive drugs in five hospitals in Suzhou were selected. Eighteen drug selection sets were designed by using discrete selection experiment (DCE) to investigate the selection of drugs by hypertensive patients. The influence of six drug attributes on patients'drug preference was analyzed by using conditional Logistic regression model. Results The six drug attributes included in the study have an impact on the drug selection preference of patients with hypertension (all P＜0.05), and the three factors that have a greater impact are the effect of cardio-cerebral and renal protection, the effect of blood pressure reduction and adverse reactions in turn. However, the effects of step-down speed, daily cost and action time are less. Conclusion Compared with the three control drugs, Levamlodipine Besylate antihypertensive drugs are more likely to be selected. The results of this study provide certain reference basis for the development of antihypertensive drugs and patients' selection of antihypertensive drugs.