我国基本药物制度实施效果研究进展评述

摘要

目的：系统评价国家基本药物制度实施效果的研究进展，为进一步完善该制度提供参考。方法：检索有关我国基本药物制度实施的国内外研究文献及国际组织报告，时间跨度为2009年1月—2014年12月。结果：最终纳入文献1292篇，其中中文1277篇，英文12篇，研究报告3篇。近年来我国基本药物制度研究文献众多，但评价技术及指标不够完善，样本代表性不足，证据连续性欠缺，利用医学大数据开展的循证评价研究刚刚起步，国际合作研究较少。结论与建议：我国基本药物制度评价研究亟待加强。基本药物制度评价既要立足国情，又要与国际的多维度评价框架相结合，从可获得性、可支付性及合理用药等方面进行深入研究，为基本药物制度的推进实施提供科学的证据支持。%Objective:To conduct a systematic review on the implementation effects of National Essential Medi-cine System ( NEMS) since the new health care reform and provide some suggestions to further improve the NEMS. Methods:Databases and relevant international organization reports were searched to collect studies related to the im-plementation of NEMS in China. The database search occurred from January 2009 to December 2014. Results:A to-tal of 1 292 studies were finally included, encompassing 1,277 Chinese papers, 12 English papers, and 3 WHO/HAI reports. A lot of researches have been done on NEMS, but the techniques of NEMS evaluation are not perfect. The sample representativeness is poor, and the longitudinal follow-up studies of the microscopic view is insufficient. . Evi-dence-based evaluation research using big data has just started. Conclusions: The research on NEMS should be strengthened. The NEMS evaluation should not only be based on national conditions, but it should also be in combi-nation with an international, multidimensional evaluation framework in terms of availability, affordability and rational drug use, so as to provide evidences to perfect the NEMS.