机关职业人群高尿酸血症与心血管疾病危险因素相关性调查

摘要

目的 调查机关职业人群高尿酸血症(HUA)患病率,分析心血管疾病危险因素与HUA患病的相关性.方法 对北京市2014~2016年参加健康体检的4735名机关干部和公务员进行横断面调查,应用Logistic回归分析HUA患病率与超重或肥胖、高血压、高血糖和血脂异常检出率的相关性.结果 总体HUA患病率为8.91﹪,其中男性为9.86%,女性为5.87%,男性HUA患病率高于女性(P<0.01).男性HUA患病的独立危险因素为血脂异常、高血压、超重或肥胖(P<0.01);女性HUA患病的独立危险因素为年龄、血脂异常、高血糖、高血压、超重或肥胖(P<0.05).结论 HUA的发生与心血管疾病危险因素中的超重或肥胖、血脂异常和高血压的关联强度较为明显,需建立以饮食治疗和改善生活方式为基础的干预措施,以减少相关危险因素的暴露水平.%Objective To investigate the morbidity of hyperuricemia (HUA) in government office staff,and analyze the associations of the cardiovascular disease risk factors with HUA in them. Methods A total of 4,735 military officers and civil servants who underwent physical examination from 2014 to 2016 were selected to do a cross-sectional study. Logistic regression analysis of the associations of HUA morbidity with the detection rate of overweight or obesity,hypertension,hyperglycemia and dyslipidemia was carried out. Results The overall HUA morbidity is 8.91%,and 9.86% in males,5.87% females. The HUA prevalence morbidity in males was higher than that in females (P<0.01). The independent risk factors to suffer HUA in males were dyslipidemia,hypertension,and overweight or obesity (P < 0.01);The independent risk factors to suffer HUA in females were age, dyslipidemia,hyperglycemia,hypertension,and overweight or obesity(P<0.05,P<0.01). Conclusion The associations of HUA with the cardiovascular disease risk factors,including overweight or obesity,dyslipidemia and hypertension,are obvious. It is needed to take intervening measures on the basis of dietary therapy and life-style correction ,so as to reduce the exposure level of the related risk factors.