Objective To observe the effects of moderate-intensity treadmill exercise on bone mineral content of humerus in ovariec-tomized (OVX) rats. Methods Thirty adult female SD rats were randomly divided into following three groups according to their body weight: sham-operation (Sham) , OVX static (OVX) , and OVX exercised (EX, 18 m/min, 45 min/d, 5 uphill, 4 times/w) groups. At 14 w of the training or 16w of the detraining, the serum content of calcium( Ca) and phosphorus ( P) were measured by colorimetry. The humeral wet weight, the humeral fat-free dry weight, and the humeral ash weight were calculated by sensitive balance. Results At 16w or 32w after OVX, the serum content of Ca, the ratio of wet weight to body weight, the ratio of fat-free dry weight to body weight and the ratio of ash weight to body weight in OVX group were significantly lower than those of sham group, and the serum Ca content had significant difference between the two groups only at 16 w, while there was no difference in the serum P content among the three groups. At the end of the training, the ratio of wet weight to body weight, the ratio of fat free dry weight to body weight and the ratio of ash weight to body weight in EX group were significantly higher than those of OVX group. However, all differences disappeared at the end of detraining, and there were no differences in serum Ca and P contents between EX-detraining group and OVX group. Conclusions The moderate-intensity treadmill exercise could mitigate the mineral loss of humerus in OVX rats.%目的 观察中等强度跑台运动对去卵巢大鼠肱骨无机矿物质含量的影响.方法 将60只成年雌性SD大鼠按体重随机分为假手术组、去卵巢静止组和去卵巢运动组,每组20只.去卵巢运动组每周进行4次时间45 min、速度18 m/min、跑道倾角5°的跑台训练,持续训练14w.末次训练24～36 h后或停训16 w时处死各组一半大鼠,比色法测定血清钙磷水平;1/万天平称量肱骨湿重、去脂肪干重以及煅烧后的灰重.结果 去卵巢16 w和32 w时,去卵巢静止组肱骨湿重/体重、肱骨去脂肪干重/体重和肱骨灰重/体重均显著低于假手术组(P＜0.05);血钙水平的差异只在去卵巢16 w时显著(P＜0.05),而血磷水平无显著变化.训练刚结束时,去卵巢运动组肱骨湿重/体重、肱骨去脂肪干重/体重和肱骨灰重/体重显著高于去卵巢静止组(P＜0.05,P＜0.01),但所有差异在停训16 w时消失;血钙、血磷水平均无显著变化.结论 中等强度跑台运动能减缓去卵巢大鼠肱骨无机矿物质含量的丢失.
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