老年男性前列腺体积变化的影响因素

摘要

目的 探讨老年男性前列腺体积变化的相关影响因素.方法 选取老年男性受试者107例,血清学检查包括测定生化指标及糖化血红蛋白、前列腺特异抗原,完成前列腺超声及动态血压监测,平均随访4年后再次复查相同检查.计量资料组间比较用配对样本t检验,组间率或构成比的比较采用x2检验,多因素分析采用多元逐步回归法.结果 随访4年后,受试者平均前列腺体积为(39.7±19.1)ml,明显高于基线(32.7±15.1)ml,增加率为21.4％,差异具有统计学意义(P ＜0.001).多元线性回归分析以前列腺体积差为因变量,舒张压(P =0.026)、体重指数(P=0.041)与前列腺体积差独立相关.结论 在老年男性人群中,舒张压、体重指数是前列腺体积增大的危险因素.%Objective To describe the prostate volume (PV) and its influencing factors in the elderly men. Methods 107 elderly men from the departments of gerontology were investigated. Ambulatory blood pressure monitoring and ultrasound examination of prostate as well as the measurements of blood chemistry were analyzed at baseline and in the follow-up. Differences in quantitative variables were tested by paired-sample t test. Multiple stepwise linear regression analysis was performed to identify determinants of PV difference. Results There was significant higher PV in the follow-up than that at baseline [ (39. 7 ± 19. 1) ml & (32. 7 ± 15. 1) ml, P < 0. 001 ]. Multiple stepwise lin ear regression analyses demonstrated that DBP and BMI were correlated with PV difference, and the association remained statistically signifi cant after adjusting for age, systolic blood pressure, TCHO, LDL-C, TG, fasting blood glucose, serum creatinine and total PSA. Conclusions In the elderly men, DBP, BMI are independent risk factors for PV.