Obej ctive To investigate the value of the expression level of adenomatous polyposis coli ( APC) gene truncated in the early diagnosis of colorectal adenoma and colon carcinoma .Methods 34 cases of colorectal cancer specimens were collected as colorectal cancer group ,28 cases of colorectal adenoma specimens as colorectal adenoma group and normal colorectal tissue specimens of 15 cases as normal group .The protein truncation test were used to compare differential expression of APC gene protein in three groups .Results APC protein truncation (+) of normal group was 0%,that of colorectal adenoma group and colorectal cancer group was 42.86%,47.06%,there was not statistically significance between colorectal adenoma and colorectal cancer group (P>0.05);normal tissues and colorectal adenoma , colorectal cancer APC protein truncation (+) but there was significant difference between normal and colorectal adenoma group and between normal and colorectal cancer group (χ2=8.917,P=0.003,χ2=10.481,P=0.001); APC protein truncation (+)of tubular adenoma tissue was 75%,significantly higher than that of villous adenomas (20.00%)and mixed adenoma(16.67%) (P<0.05).Conclusions The trun-cated APC protein (+) expression is different in different tissues in the early stage of APC ,which might play a certain role in the early diag-nosis of colorectal tumor .%目的：探讨腺瘤样结肠息肉（ APC）易感基因截短表达水平在大肠腺瘤及大肠癌早期诊断中的价值。方法34例大肠癌病理标本作为大肠癌组、28例大肠腺瘤标本作为大肠腺瘤组及同期正常大肠组织标本15例作为正常组。3组分别采用蛋白截短检测技术，比较APC基因蛋白截短表达差异。结果正常组APC蛋白截短（＋）为0％，大肠腺瘤组42．86％，大肠癌组47．06％，大肠腺瘤组和大肠癌组差异不显著（ P＞0．05）；正常组与大肠腺瘤、大肠癌组差异显著（χ2＝8．917、 P＝0．003，χ2＝10．481、 P＝0．001）；管状腺瘤组织的 APC 蛋白截短（＋）（75．00％），显著高于绒毛腺瘤组织（20．00％）和混合腺瘤组织（16．67％）（P＜0．05）。结论 APC蛋白截短（＋）表达在不同大肠组织中表达具有一定的差异性，在大肠肿瘤的早期阶段APC蛋白截短（＋）表达就存在差异，对早期诊断大肠肿瘤病变具有一定的意义。
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