糖尿病患者甲襞微循环病变及其与颈动脉内－中膜厚度的相关性

摘要

Objective To research the microangiopathy of diabetes and its correlation with the macrocirculation .Methods 78 cases of type 2 diabetes mellitus(T2DM)were divided into experimental and control groups and the nail fold microcirculation (NFM)of all the cases were tested.The patients of T2DM were divided into NFM≤median and NFM>median subgroups .The correlation between NFM and internal medial thickening(IMT)of carotid artery were analyzed.Results The scores of cross,deformed,ooze and bleeding,aggregation of red blood cells of experimental group were higher than those of control group .The frequence of IMT thicker of NFM>median subgroup was more than that of NFM≤median subgroup.Conclusions The main microcirculation changes of T2DM are cross,deformed,ooze and Bleeding,aggrega-tion of red blood cells .There is closely associated with microvascular and macrovascular in diabetic .%目的：探讨2型糖尿病患者微血管病变特征及其与大血管病变的相关性。方法将78例2型糖尿病患者设为试验组与40例正常对照组进行对比，分别进行甲襞微循环检测，分析2型糖尿病患者微血管病变特征；采用中位数法将糖尿病人按甲襞微循环总分（ NFM ）分为积分≤中位数（ NFM≤median）和积分＞中位数（ NFM＞median）两部分，分析其与颈动脉内－中膜厚度及斑块形成的相关性。结果试验组甲襞微循环的交叉、畸形、渗出、出血、红细胞聚集五项积分高于对照组；NFM＞median患者颈动脉内－中膜增厚出现频次高于 NFM≤median患者（ P＜0．05）；NFM＞me－dian患者颈动脉斑块出现频次高于 NFM≤median患者（ P＜0．05）。结论2型糖尿病患者微循环病变主要表现为交叉、畸形、红细胞聚集、袢周渗出、出血；糖尿病患者微血管与大血管病变密切相关。