晚蚕沙外熨治疗寒凝血瘀型糖尿病周围神经病变的初步探讨

摘要

目的 探讨晚蚕沙外熨对糖尿病性周围神经病变寒凝血瘀症患者血糖、血脂及血浆同型半胱氨酸(Hcy)的影响. 方法 260例糖尿病性周围神经病变寒凝血瘀症患者随机分为对照组(130例)与观察组(130例).对照组给予甲钴胺500 μg,3次/d,口服.观察组给予甲钴胺500 μg,3次/d,口服联合晚蚕沙外熨肢体麻凉痛部位.两组患者4周为1个疗程,1个疗程后观察两组患者血糖、血脂及血浆Hcy各项指标变化. 结果 治疗后两组血脂、血液流变学均有明显改善,观察组较对照组改善更加明显(P＜0.05);治疗后两组血浆Hcy水平均有明显降低,观察组血浆Hcy水平低于对照组(P＜0.05). 结论 晚蚕沙外熨能有效改善血糖、血脂代谢,降低血浆Hcy水平,对糖尿病周围神经病变具有较好的防治作用.%Objective To investigate the effects of silkworm excrement ironing on blood levels of glucose,lipids and Hcy in diabetic peripheral neuropathy patients with cold coagulation and blood stasis.Methods A total of 260 diabetic peripheral neuropathy patients with cold coagulation and blood stasis were randomly divided into the control group(n=130)and the observation group(n=130).Both groups were treated with oral methylcobalamin(500 μg,tid),and in addition,the observation group was given silkworm excrement ironing on areas of the limb with numbness and pain.Patients underwent one single course of treatment lasting 4 weeks.Blood levels of glucose,lipids and Hcy preand post treatment were analyzed.Results Blood lipid profiles and hemorheology improved in both groups after treatment,compared with pre-treatment data,and greater improvement was seen in the observation group than in the control group(all P＜0.05).Plasma Hcy levels decreased in both groups after treatment,compared with pre-treatment levels,and deeper decline was seen in the observation group than in the control group after treatment(all P＜0.05).Conclusions Silkworm excrement ironing can effectively improve the blood glucose profile and lipid metabolism,reduce plasma Hcy levels and may exert beneficial preventive and therapeutic effects on diabetic peripheral neuropathy.