非那雄胺预防前列腺增生急性尿潴留的临床观察

摘要

Objective To study the effect of finasteride on preventing prostate hyperplasia with acute urinary retention.Methods Totally 626 patients with benign prostatic hyperplasia (BPH) were randomly divided into treatment group (316 cases) and control group (310 cases),followed up for 3 years.The incidence of acute urinary retention and prostate volume changes were analyzed.Results There were 3 cases of acute urinary retention in treatment group (1.0 ％),9 cases in control group (2.9％) (x2 ＝5.37,P＜0.05).In treatment group,the average prostate volume was reduced about 23.6％ compared with before taking the medicine,on the contrary,prostate volume was averagely increased 12.3％ in control group.Conclusions Finasteride can reduce the risk of acute urinary retention by narrowing the prostate volume in patients of benign prostatic hyperplasia.%目的 观察非那雄胺预防前列腺增生急性尿潴留的疗效.方法 626例良性前列腺增生(BPH)患者分为治疗组316例与对照组310例,随访3年,对急性尿潴留的发生率和前列腺体积的变化进行对比.结果 治疗组急性尿潴留3例(1.0％)、对照组13例(4.2％),两组比较差异有统计学意义(x2 ＝5.37,P＜0.05),治疗组前列腺的体积较服药前平均缩小23.6％,对照组观察期间前列腺的体积平均增大12.3％.结论 非那雄胺通过缩小前列腺的体积降低BPH急性尿潴留发生的风险.