老年2型糖尿病患者血清心肌肌钙蛋白水平与心血管事件的相关性研究

摘要

目的 探讨老年2型糖尿病患者血清心肌肌钙蛋白水平与心血管事件的相关性,为2型糖尿病并发心血管疾病的预防和诊治提供依据.方法 回顾性分析,选择我院老年2型糖尿病患者200例,根据患者的血清心肌肌钙蛋白水平分为肌钙蛋白阳性组(30例)和肌钙蛋白阴性组(170例).比较两组患者的心血管事件及心血管事件死亡的发生情况.结果 心肌肌钙蛋白阳性组的果糖胺、血红蛋白水平低于心肌肌钙蛋白阴性组(P＜0.05),C反应蛋白水平高于心肌肌钙蛋白阴性组(P＜0.05).心肌肌钙蛋白阳性组的心血管事件发生率63.3％ (19/30)和心血管事件病死率26.7％(8/30)均高于心肌肌钙蛋白阴性组的4.1％(7/170)、1.2％(2/170),差异有统计学意义(x2值分别为73.45、28.44,均P＜0.05).结论 心肌肌钙蛋白水平高的患者的血清果糖胺和血红蛋白水平较低,C反应蛋白水平较高.糖尿病患者的血清心肌肌钙蛋白水平与心血管事件的发生有关.%Objective To study the correlation of serum cardiac troponin levels and cardiovascular events in elderly type 2 diabetes patients,and provide the basis for prevention and treatment of cardiovascular disease combined with type 2 diabetes mellitus.Methods Totally 200 elderly type 2 diabetes patients were selected in the First Affiliated Hospital of Zhengzhou University,and divided into cardiac troponin-positive and negative groups according to serum cardiac troponin levels.The incidence of cardiovascular events and mortality was compared between the two groups.Results The levels of fructosamine and hemoglobin in cardiac troponin-positive group were significantly lower than those of cardiac troponin-negative group (P＜0.05).The C-reactive protein levels were increased in cardiac troponin-positive versus negative group (P ＜0.05).The incidences of cardiovascular events and mortality in cardiac troponin-positive group showed higher than those of cardiac troponin-negative group[63.3％ (19/30)vs.4.1 ％ (7/170),26.7％ (8/30) vs.1.2％ (2/170),x2 =73.45,28.44,all P＜0.05].Conclusion Lower levels of serum fructosamine and hemoglobin,higher C-reactive protein level exist in diabetes patients with high cardiac troponin levels.The serum cardiac troponin level has a certain relationship with cardiovascular events in diabetes patients.