阿尔茨海默病与白内障

摘要

阿尔茨海默病(AD)是一种进行性的与年龄相关的神经系统变性疾病,作为老年痴呆性疾病中最常见的类型,目前仍无有效的早期诊断方法和手段.AD病理表现为细胞内的淀粉样斑块及细胞外的神经纤维缠结.过度聚集的β淀粉样蛋白(Aβ)是导致AD发病的中心环节.AD患者除了记忆及认知功能障碍,尚有眼部症状.有研究发现,Aβ不仅在脑内发生沉积,也可在晶状体内发生类似改变.而晶状体结构及位置的特殊性,决定了其具有大脑不具备的可直观检查的优越性,可为AD的早期诊断提供简单方便快捷的方法.因此,值得引起重视及深入探究内在的具体关联.%Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease.As the most common type of senile dementia disease,AD has no effective methods for early diagnoses.AD is characterized by the deposition of intracellular amyloid β (Aβ) plaques and extracellular neurofibrillary tangles (NFT) in the brain.In addition to allomnesia and cognitive disorder,ocular manifestation such as cataracts exists in AD patients.Studies have shown that amyloid-β (Aβ) is deposited not only in the brain but also in crystalline lens.For its structure and special location,crystalline len is more accessible for imaging than the brain,which can provide a simple,convenient and early diagnosis method for AD.Hence,it is worth investigating the relationship between Alzheimer's disease and cataracts.