衰弱在老年慢性肾脏疾病的研究进展

摘要

The management of frailty in elderly patients with chronic kidney disease (CKD) has been receiving increasing attention.Frailty in elderly patients with CKD has a high incidence and is used for risk prediction of adverse outcomes,including death,hospitalization,falls,dialysis and so on.A range of pathophysiological changes caused by CKD,aging and multimorbidity work together to promote the development of frailty.Treatment for CKD patients with frailty includes mainly nutritional support,exercise,drug therapy and comprehensive intervention.This article reviews recent research progress concerning frailty in elderly CKD patients.%衰弱在老年慢性肾脏疾病(CKD)患者中的研究日益受到重视.衰弱在老年CKD患者中发病率较高,且是CKD不良预后的风险预测值,包括死亡、再住院、跌倒、透析等.CKD引起的一系列病理生理改变与老化、共病共同促进衰弱的发生.CKD患者衰弱的治疗主要包括营养支持、运动训练、药物治疗及综合干预.本文就衰弱与老年CKD相关研究进展进行综述.