额叶功能评定量表在识别血管性认知障碍两亚型患者中的作用

摘要

目的 比较血管性认知障碍(VCI)两亚型患者中额叶功能评定量表(FAB)6个亚功能得分差异,为两型患者区别性干预治疗,病情防控提供线索. 方法 选择某医院神经内科220例非痴呆性血管性认知障碍(VCIND)和68例血管性痴呆(VaD)确诊患者,FAB量表测验其额叶整体功能和6个亚功能得分.分析两者得分差异,并探究VCIND进行性发展到VaD阶段其额叶功能恶化趋势. 结果 VCIND和VaD患者的FAB总分差异有统计学意义[(14.0±2.3)分比(9.5±2.0)分,t=29.92,P=0.00];具体比较FAB量表中概念化能力(t=6.24,P=0.00)、智能灵活性(t=7.00,P=0.00)、抗干扰能力(t=7.21,P=0.00)、注意抑制力(t=5.32,P=0.00)4个亚功能得分,均为VaD显著差于VCIND患者;VaD相比VCIND患者,其概念化能力权重下降明显(0.32降至0.04). 结论 随着VCI病情发展,VCIND向VaD过渡的过程中需着重预防其概念化能力的突变恶化.%Objective To compare 6 sub-function scale differences of frontal lobe function rating scale or a Frontal Assessment Battery(FAB)among patients with two subtypes of vascular cognitive impairment(VCI) to provide clues for the distinctive intervention and disease prevention and control of patients with two subtypes.Methods Totally 220 non-dementia vascular cognitive impairment (NDVCI)patients and 68 patients with vascular dementia(VaD)with final diagnosis were selected.The overall function and six sub-function scores were tested by FAB.Analyzing the score difference and probing a progress tendency from NDVCI to VaD were performed.Results The scores of frontal lobe function rating scale were higher in NDVCI(14.0 ± 2.8)than in VaD (9.5±2.0) patients with significant difference(t =29.92,P =0.00).The scales of frontal lobe function rating score of conceptualization ability (t =6.24,P =0.00),intelligence flexibility (t =7.00,P =0.00),antiinterference ability(t =7.21,P =0.00) and attention suppression(t =5.32,P =0.00) were lower in VaD group than in NDVCI group.The conceptualization weight capacity was significantly lower in VaD group than in NDVCI group(0.04 versus 0.32).Conclusions During a transitive process from NDVCI to VaD,it is important to focus on the mutation and deterioration of conceptualization capacity.