急性ST段抬高心肌梗死患者白细胞计数与肌酸激酶同工酶及肌钙蛋白T峰值的相关分析

摘要

目的 探讨急性ST段抬高心肌梗死(ST-elevation myocardial infarction,STEMI)患者入院即刻WBC计数与肌酸激酶同工酶(CK-MB)及肌钙蛋白T(cTnT)峰值的相关性,及WBC作为心肌坏死面积大小指标的可靠性.方法 连续入选2010年1月～2011年6月就诊于北京友谊医院的初发STEMI患者212例,按入院即刻外周血WBC水平分为正常组(WBC＜10×109/L)120例,升高组(WBC≥10×109/L)92倒.比较2组患者CK-MB及cTnT峰值的差异,并分析WBC与CK-MB、cTnT峰值的相关性.结果 与正常组比较,升高组患者舒张压、TG、CK-MB及cTnT峰值明显升高,差异有统计学意义(P＜0.05,P＜0.01);多元逐步回归分析显示,WBC与CK-MB和cTnT峰值呈正相关(r=0.636,r=0.539,P＜0.05).结论 STEMI的入院即刻WBC水平与CK-MB及cTnT峰值升高程度呈显著线性正相关,WBC是反应STEMI患者心肌坏死面积大小的良好指标.%Objective To study the WBC as a reliable indication for myocardial infarction by observing the correlation of WBC count with the peak creatine kinase myocardial band(CK-MB) and cardiac troponint T(cTnT) values in patients with acute ST-elevation myocardial infarction (STEMI) at admission. Methods Two hundred and twelve acute STEMI patients, admitted to our hospital from January 2010 to June 2011,were divided into normal WBC group(n=120) with their WBC<10×109/L and increased WBC group(n = 92) with their WBC<10×109/L. Difference in their peak CK-MB and cTnT values was compared and correlation of WBC count with peak CK-MB and cTnT values was analyzed. Results The diastolic blood pressure, TG, peak CK-MB and cTnT values were significantly higher in increased WBC group than in normal WBC group(P<0. 05 ,P<0. 01), Multiple stepwise regression analysis showed that the WBC count was positively correlated with the peak CK-MB and cTnT values(r=0. 636 and 0. 539,P<0. 05). Conclusion The WBC count is positively correlated with the peak CK-MB and cTnT values in STEMI patients at admission in a sigficant linear manner, indicating that WBC count is a good indication for myocardial infarction size in STEMI patients.