Objective To investigate the adverse reaction and effectiveness of oral low dose aspirin in the patients at the age of 75 and older. Methods During January 2010 to May 2011, the patients with cardiovascular and/or cerebrovascular diseases and/or diabetes who had taken enteric-coated aspirin l00mg/d were investigated. 226 patients aged 75 years and older were defined as the senior group,270 patients below 75 as the adult group. The adverse reactions between two groups were compared. Additionally,the platelet aggregation rate in the patients taking aspirin including 178 senior ones and 249 adult ones was tested. Results The incidence of adverse reactions in senior group was significantly higher than that in adult group(43. 8% vs 23. 7% ,P<0. 01),while the difference in platelet aggregation rate between two groups was not statistically significantdl. 3% vs 12. 7% ,P>0. 05). Conclusions The effectiveness of taking long-term low dose aspirin among patients at the age of 75 and older is similar to that in adults. However,the adverse reactions were definitely increased in elderly. Therefore,carefully evaluating risks and closely monitoring during medication are important.%目的 调查小剂量肠溶阿司匹林在年龄≥75岁老年患者中使用的不良反应及有效性.方法 选择长期服用肠溶阿司匹林100 mg/d的心脑血管病及糖尿病患者,年龄≥75岁226例(老年组),年龄＜75岁270例(成年组),比较2组在服用阿司匹林过程中的不良反应.另对坚持服用阿司匹林的老年组患者178例,成年组患者249例检测血小板聚集率.结果 老年组阿司匹林不良反应发生率明显高于成年组(43.8％ vs 23.7％,P＜0.01).老年组与成年组血小板聚集率差异无统计学意义(11.3％ vs 12.7％,P＞0.05).结论 年龄≥75岁老年人长期服用小剂量肠溶阿司匹林与成年人同样有效,但不良反应明显增加,需要仔细评价风险并密切监测.
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