胃肠道粘膜相关淋巴组织淋巴瘤的细胞凋亡及其基因调控

摘要

Objective　To investigate the apoptosis and expression of bcl-2 and p53 relevant to the histological grade and prognosis in patients with gastrointestinal MALT lymphoma.Methods　32 gastrointestinal MALT lymphoma cases from 1990 to 1998 were enrolled.HE and immunohistochemical staining and apoptosis by TUNEL were carried out in all cases.Results　23 out of 32 cases were at high levels of apoptosis and the remaining 9 at low levels.bcl-2 expression was positive in 10 cases and negative in 22 cases.p53 expression was positive in 14 and negative in 18 cases.The apoptosis and the expression of bcl-2 were at negative correlation.Conclusion　Apoptosis status and bcl-2 expression could be used to predict the prognosis of patients with gastrointestinal MALT lymphoma.%目的探讨细胞凋亡和bcl-2及p53蛋白在胃肠道粘膜相关淋巴组织(MALT)淋巴瘤中的表达与MALT淋巴瘤恶性程度及预后的关系。方法收集我院1990年1月～1998年12月胃肠道MALT淋巴瘤32例，行免疫组织化学染色方法检测bcl-2和p53蛋白的表达，应用原位末端标记法进行细胞凋亡检测。结果本组32例中凋亡细胞呈低密度9例、高密度23例；bcl-2蛋白表达阴性22例、阳性10例；p53蛋白表达阴性18例、阳性14例。细胞凋亡与bcl-2蛋白表达呈负相关，与p53蛋白表达无关。结论凋亡细胞密度和bcl-2蛋白表达对判断胃肠道MALT淋巴瘤的恶性程度和预后均有帮助。