2型糖尿病患者颈动脉粥样硬化与总胆红素的关系

摘要

Ultrasonography examinations were performed for carotid atherosclerosis in 548 patients with type 2 diabetes mellitus (T2DM). Blood glucose, glycosylated hemoglobin, total serum bilirubin, uric acid, total cholesterol ( TC ), triglycerides ( TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL) were measured. Total serum bilirubin level in T2DM patients without carotid atherosclerosis was (13.0±7. 1 )μmol/L, while that was (10. 9 ± 4. 9 )μmol/L in patients with carotid atherosclerosis (P ＜0. 01 ). The logistic analysis showed that total serum bilirubin level was negatively related to the presence of carotid atherosclerosis ( P ＜ 0. 05 ), which indicated that higher level of total serum bilirubin might be a protective factor for macroangiopathy in T2DM.%对548例2型糖尿病患者行颈动脉超声检查,比较分析有、无颈动脉粥样硬化患者的血糖、糖化血红蛋白、胆红素、血脂等指标差异.有、无动脉粥样硬化患者的血清胆红素水平分别为(13.0±7.1)和(10.9±4.9)μmol/L,两者之间差异有统计学意义(P＜0.01);logistic回归分析显示总胆红素水平与颈动脉粥样硬化呈负相关(P＜0.05).提示高血清胆红素可能对2型糖尿病大血管病变具有保护作用.