胆汁酸在脂类的消化、吸收中起十分重要的作用。顶端钠离子/胆汁酸转运体（ ASBT）位于回肠刷状缘侧，发挥重吸收胆汁酸的作用，对于维持机体胆汁酸稳态具有重要意义。近年来，关于ASBT的表达调控及其与肠道炎症、肿瘤、肠道分泌、运动和感觉功能、肠道微生态、肠-肝轴等关系的研究提示其在一些消化道疾病中发挥重要作用，有望成为这些疾病新的治疗靶点。本文就相关研究进展作一综述。%Bile acids play critical roles in the solubilization and absorption of lipids. The ileal apical sodium-dependent bile acid transporter( ASBT)located at the enterocyte brush border is responsible for the reuptake of bile acids and the maintenance of bile acid homeostasis. Recently,great success has been made in understanding the relationship between ASBT and intestinal inflammation,tumorigenesis,secretion,motility,sensation,gut microbiota,and gut-liver axis in addition to its expression regulation,which implicates ASBT as a contributor of some gastrointestinal diseases and a promising new therapeutic target for these diseases. In this review article,the advances in study on above-mentioned issues were summarized.
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