CMTM3在幽门螺杆菌感染慢性胃炎中的表达及其意义

摘要

Background: CKLF-like MARVEL transmembrane domain containing (CMTM) superfamily is involved in the occurrence and development of inflammation, cancer and a variety of diseases.Human CMTM3 has been proposed as a putative tumor suppressor gene.Aims: To investigate the expression of CMTM3 in Helicobacter pylori (Hp) infection-related chronic gastritis and its significance.Methods: Sixty cases of outpatients with chronic gastritis (30 Hp-positive and 30 Hp-negative) were enrolled for detection of CMTM3 and interleukin-6 (IL-6) expressions in gastric mucosa by immunohistochemistry.The correlation of expressions of CMTM3 and IL-6 was analyzed.Results: The positivity rates of CMTM3 and IL-6 in gastric mucosa were significantly higher in Hp-positive chronic gastritis than in Hp-negative ones (CMTM3: 63.3% vs.30.0%, P<0.05;IL-6: 73.3% vs.13.3%, P<0.01).In patients with Hp-positive chronic gastritis, CMTM3 and IL-6 were co-expressed in 53.3% (16/30) of the patients and localized in the same position.Expression of CMTM3 was positively correlated with IL-6 expression in Hp-positive chronic gastritis patients (r=0.58, P<0.05).Conclusions: CMTM3 is highly expressed in chronic gastritis patients with Hp infection.It may participate in the occurrence and development of Hp infection-related chronic gastritis with inflammatory cytokines such as IL-6.Hp infection might be one of the mechanisms involved in CMTM3 up-regulation.%背景:趋化素样因子超家族(CMTM)参与炎症、肿瘤等多种疾病的发生、发展过程.目前对CMTM3的研究主要集中在其肿瘤抑制作用方面.目的:探讨CMTM3在幽门螺杆菌(Hp)感染慢性胃炎中的表达及其意义.方法:选取Hp阳性和阴性慢性胃炎患者各30例,以免疫组化法检测胃黏膜CMTM3和白细胞介素-6(IL-6)表达,分析两者表达的相关性.结果:与Hp阴性慢性胃炎患者相比,Hp阳性慢性胃炎患者胃黏膜中CMTM3和IL-6阳性表达率均显著增高(CMTM3: 63.3%对30.0%, P<0.05;IL-6: 73.3%对13.3%, P<0.01).在Hp阳性慢性胃炎患者中,CMTM3与IL-6的共表达率为53.3%(16/30),且两者表达部位一致;相关性分析显示两者呈显著正相关(r=0.58,P<0.05).结论:CMTM3在Hp感染慢性胃炎胃黏膜中呈高表达,其可能与IL-6等炎症细胞因子共同参与了Hp感染慢性胃炎的发生、发展.Hp感染可能是引起CMTM3表达上调的机制之一.