食管原发性小细胞神经内分泌癌的临床分析:9例报道

摘要

目的 探讨食管原发性小细胞神经内分泌癌(esophageal primary small cell neuroendocrine carcinoma,ESCNC)患者的临床特点,为临床诊治提供循证医学依据.方法 回顾性分析解放军第八二医院2012年6月至2015年12月住院治疗的ESCNC患者的病例资料,共9例,比较其临床症状、检查结果、治疗效果的特点.结果 ESCNC患者多以进行性吞咽梗阻感伴有胸骨后疼痛为始发症状,放射治疗联合化疗及早期手术的预后较好,单纯放疗及化疗的患者预后较差.结论 ESCNC患者的总体预后较差,加强此病的早期诊断、合理选择治疗方法,是提高生存率的关键.%Objective To investigate the clinical characteristics of patients with esophageal primary small cell neuroendocrine carcinoma (ESCNC),and to provide evidence-based medical basis for clinical diagnosis and treatment.Metbods ESCNC patients in No.82 Hospital of PLA from Jun.2012 to Dec.2015 were analyzed retrospectively.The characteristics of clinical symptoms,examination results and treatment effects were compared.Results Patients with ESCNC were more likely to have progressive swallowing obstructions accompanied by sternal pain.The prognosis of radiotherapy combined with chemotherapy and early surgery was better.The prognosis of simple radiotherapy and chemotherapy was poor.Conclusion Overall prognosis of ESCNC patients is poor.Strengthening the early diagnosis of ESCNC,reasonable choice of treatment methods are the key to improve the survival rate.