目的：探讨去白细胞换血疗法对高胆红素血症新生患儿血浆凝血因子、白蛋白的影响。方法选取本院55例高胆红素血症新生患儿为研究对象，采取去白细胞换血疗法治疗（160 ml/kg），比较患儿治疗前后血浆凝血因子和换血即刻血清总胆红素和白蛋白水平变化。结果患儿治疗后血浆凝血因子和白蛋白水平均较治疗前降低，差异具有显著性（P＜0.05）。患儿换血即刻血清总胆红素水平较换血前显著降低，差异具有显著性（t＝7.48，P＜0.05）。结论去白细胞换血疗法治疗新生儿高胆红素血症可在保证正常治疗效果的前提下降低血浆凝血因子和白蛋白水平。%Objective To investigate the effect of De–leucocyte exchange transfusion on plasma coagu-lation factor and albumin of newborn children with high bilirubin. Method 55 cases of newborn children with high bilirubin were selectd and treated with De-leucocyte exchange transfusion (160 ml/kg). Blood plasma clotting factors before and after treatment and total bilirubin and albumin level changes immediate after treatment were compared. Result Compared with before treatment, plasma clotting factors and albumin levels were low, and the difference was statistically signiifcant (P<0.05). Blood bilirubin level immediately after treatment was signiifcantly reduced, and difference was statistically signiifcant (t = 7.48, P<0.05). Conclusion De-leucocyte exchange transfusion treating newborn children with high bilirubin can lower plasma clotting factors and albumin levels on the basis of ensuring normal healing.
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