老年2型糖尿病患者周围神经病变与25-羟维生素D3的相关性研究

摘要

ObjectiveTo discuss the relationship between peripheral neuropathy and 25-hydroxy vitamin D3 [25-(OH)D3] in elderly patients with type 2 diabetes mellitus.Method117 cases of type 2 diabetes patients with peripheral neuropathy (experimental group) and 150 cases of type 2 diabetes patients (control group) were selected as the objects of study from March 2014 to September 2015 in our hospital. The body height, weight, blood glucose, blood lipid, serum parathyroid hormone, 25-(OH)D3 levels were detected and compared between the two groups; Logistic regression analysis was used to analyze the related factors of type 2 diabetes with peripheral neuropathy.ResultThe level of 25-(OH)D3 of experimental group patients was significantly lower than control group (P<0.05); correlation analysis showed that serum 25-(OH)D3 level was positively correlated with sural nerve sensory conduction velocity, and negatively correlated with HbA1c. Logistic regression analysis showed that peripheral neuropathy was negatively correlated with age, duration of diabetes, HbA1c, and positively correlated with 25-(OH)D3 (P<0.05).ConclusionThe serum 25-(OH)D3 level of type 2 diabetes patients with peripheral neuropathy patients is significantly lower than diabetic, serum 25-(OH)D3 is closely related to the occurrence of peripheral neuropathy.%目的：分析2型糖尿病患者周围神经病变与血清25-羟维生素D3[25-（OH）D3]的相关性。方法选取2014年3月至2015年9月于本院就诊的117例2型糖尿病合并周围神经病变患者（试验组）和138例单纯2型糖尿病患者（对照组）为研究对象，检测并比较两组患者身高、体重、血糖、血脂、血清甲状旁腺激素、25-（OH）D3水平等；采用Logistic回归分析糖尿病周围神经病变的影响因素。结果试验组患者血清25-（OH）D3水平明显低于对照组（P＜0.05）；经相关分析发现，血清25-（OH） D3水平与腓肠神经感觉神经传导速度呈正相关（P＜0.05），与糖化血红蛋白（HbA1c）水平呈负相关（P＜0.05）；经Logistic回归分析发现，糖尿病周围神经病变与患者年龄、糖尿病病程、HbA1c水平呈负相关，与血清25-（OH）D3呈水平正相关（P＜0.05）。结论糖尿病周围神经病变患者血清25-（OH）D3水平明显低于单纯糖尿病患者，血清25-（OH）D3与周围神经病变的发生密切相关。